Signal-regulatory protein beta-1 is a protein that in humans is encoded by the SIRPB1 gene.[5][6][7] SIRPB1 has also recently been designated CD172B (cluster of differentiation 172B).

SIRPB1
Available structures
PDBHuman UniProt search: PDBe RCSB
Identifiers
AliasesSIRPB1, CD172b, SIRP-BETA-1, signal regulatory protein beta 1
External IDsOMIM: 603889; MGI: 3779828; HomoloGene: 82993; GeneCards: SIRPB1; OMA:SIRPB1 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001083910
NM_001135844
NM_006065
NM_001329157
NM_001330639

NM_001173460

RefSeq (protein)

n/a

Location (UCSC)Chr 20: 1.56 – 1.62 MbChr 3: 15.56 – 15.64 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

The protein encoded by this gene is a member of the signal-regulatory-protein (SIRP) family, and also belongs to the immunoglobulin superfamily. SIRP family members are receptor-type transmembrane glycoproteins known to be involved in the negative regulation of receptor tyrosine kinase-coupled signaling processes. This protein was found to interact with TYROBP/DAP12, a protein bearing immunoreceptor tyrosine-based activation motifs. This protein was also reported to participate in the recruitment of tyrosine kinase SYK. Alternatively spliced transcript variants have been found for this gene.[7]

Interactions

edit

SIRPB1 has been shown to interact with TYROBP.[8][9]

References

edit
  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000101307Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000095028Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Kharitonenkov A, Chen Z, Sures I, Wang H, Schilling J, Ullrich A (April 1997). "A family of proteins that inhibit signalling through tyrosine kinase receptors". Nature. 386 (6621): 181–6. Bibcode:1997Natur.386..181K. doi:10.1038/386181a0. PMID 9062191. S2CID 4259314.
  6. ^ van den Berg TK, van Beek EM, Buhring HJ, Colonna M, Hamaguchi M, Howard CJ, Kasuga M, Liu Y, Matozaki T, Neel BG, Parkos CA, Sano S, Vignery A, Vivier E, Wright M, Zawatzky R, Barclay AN (December 2005). "A nomenclature for signal regulatory protein family members". J Immunol. 175 (12): 7788–9. doi:10.4049/jimmunol.175.12.7788. PMID 16339511. S2CID 41479985.
  7. ^ a b "Entrez Gene: SIRPB1 signal-regulatory protein beta 1".
  8. ^ Dietrich J, Cella M, Seiffert M, Bühring H J, Colonna M (January 2000). "Cutting edge: signal-regulatory protein beta 1 is a DAP12-associated activating receptor expressed in myeloid cells". J. Immunol. 164 (1). UNITED STATES: 9–12. doi:10.4049/jimmunol.164.1.9. ISSN 0022-1767. PMID 10604985.
  9. ^ Tomasello E, Cant C, Bühring H J, Vély F, André P, Seiffert M, Ullrich A, Vivier E (August 2000). "Association of signal-regulatory proteins beta with KARAP/DAP-12". Eur. J. Immunol. 30 (8). GERMANY: 2147–56. doi:10.1002/1521-4141(2000)30:8<2147::AID-IMMU2147>3.0.CO;2-1. ISSN 0014-2980. PMID 10940905. S2CID 84258013.

Further reading

edit
edit

This article incorporates text from the United States National Library of Medicine, which is in the public domain.