SEPT2

Septin 2, also known as SEPT2, is a protein which in humans is encoded by the SEPT2 gene.

SEPTIN2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2QA5, 2QAG, 2QNR
Identifiers
Aliases	SEPTIN2, DIFF6, NEDD-5, NEDD5, Pnutl3, hNedd5, septin 2, SEPT2
External IDs	OMIM: 601506; MGI: 97298; HomoloGene: 3243; GeneCards: SEPTIN2; OMA:SEPTIN2 - orthologs
Gene location (Human) Chr. Chromosome 2 (human) Band 2q37.3 Start 241,315,100 bp End 241,354,027 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in ventricular zone optic nerve germinal epithelium secondary oocyte parietal pleura corpus callosum visceral pleura endometrium external globus pallidus Achilles tendon n/a More reference expression data BioGPS More reference expression data
Gene ontology Molecular function nucleotide binding GTP binding protein binding cadherin binding identical protein binding GTPase activity molecular adaptor activity Cellular component cytoplasm cell projection membrane plasma membrane spindle septin complex chromosome photoreceptor connecting cilium cell cortex exocyst midbody nucleolus ciliary membrane actin cytoskeleton perinuclear region of cytoplasm axoneme cleavage furrow chromosome, centromeric region cytoskeleton extracellular exosome nucleus kinetochore cytosol sperm annulus non-motile cilium cilium septin ring microtubule cytoskeleton motile cilium Biological process cell division cell cycle neuron projection development spermatogenesis cell differentiation smoothened signaling pathway cilium assembly cytoskeleton-dependent cytokinesis Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 4735 18000 Ensembl ENSG00000168385 n/a UniProt Q15019 P42208 RefSeq (mRNA) NM_001008491 NM_001008492 NM_001282972 NM_001282973 NM_004404 NM_006155 NM_001321029 NM_001321030 NM_001321031 NM_001321032 NM_001321033 NM_001321034 NM_001321035 NM_001349287 NM_001349288 NM_001349289 NM_001349290 NM_001349291 NM_001349302 NM_001349304 NM_001349305 NM_001349306 NM_001349307 NM_001349308 NM_001349309 NM_001349310 NM_001349311 NM_001349312 NM_001349313 NM_001349314 NM_001349315 NM_001159717 NM_001159718 NM_001159719 NM_010891 RefSeq (protein) NP_001008491 NP_001008492 NP_001269901 NP_001269902 NP_001307958 NP_001307959 NP_001307960 NP_001307961 NP_001307962 NP_001307963 NP_001307964 NP_004395 NP_006146 NP_001336216 NP_001336217 NP_001336218 NP_001336219 NP_001336220 NP_001336231 NP_001336233 NP_001336234 NP_001336235 NP_001336236 NP_001336237 NP_001336238 NP_001336239 NP_001336240 NP_001336241 NP_001336242 NP_001336243 NP_001336244 NP_001153189 NP_001153190 NP_001153191 NP_035021 Location (UCSC) Chr 2: 241.32 – 241.35 Mb n/a PubMed search
Wikidata
View/Edit Human View/Edit Mouse

Function

SEPT2 can hetero-oligomerize with SEPT6 and SEPT7 to form filaments. SEPT2 interacted with SEPT6 through its C-terminal coiled-coil domain. Knockdown of SEPT2, SEPT6, and SEPT7 in causes actin stress fibers to disintegrate and cells to lose polarity. Septins, SOCS7, and NCK1 are part of a signaling pathway that ties regulation of the DNA damage response to the cytoskeleton.

Interactions

SEPT2 has been shown to interact with:

• SEPT6
• SEPT7, and
• SEPT9.

Further reading

• Nagase T, Seki N, Tanaka A, Ishikawa K, Nomura N (August 1995). "Prediction of the coding sequences of unidentified human genes. IV. The coding sequences of 40 new genes (KIAA0121-KIAA0160) deduced by analysis of cDNA clones from human cell line KG-1". DNA Research. 2 (4): 167–74, 199–210. CiteSeerX 10.1.1.333.6945. doi:10.1093/dnares/2.4.167. PMID 8590280.
• Mori T, Miura K, Fujiwara T, Shin S, Inazawa J, Nakamura Y (1996). "Isolation and mapping of a human gene (DIFF6) homologous to yeast CDC3, CDC10, CDC11, and CDC12, and mouse Diff6". Cytogenetics and Cell Genetics. 73 (3): 224–7. doi:10.1159/000134343. PMID 8697812.
• Kinoshita M, Kumar S, Mizoguchi A, Ide C, Kinoshita A, Haraguchi T, Hiraoka Y, Noda M (June 1997). "Nedd5, a mammalian septin, is a novel cytoskeletal component interacting with actin-based structures". Genes & Development. 11 (12): 1535–47. doi:10.1101/gad.11.12.1535. PMID 9203580.
• Hsu SC, Hazuka CD, Roth R, Foletti DL, Heuser J, Scheller RH (June 1998). "Subunit composition, protein interactions, and structures of the mammalian brain sec6/8 complex and septin filaments". Neuron. 20 (6): 1111–22. doi:10.1016/S0896-6273(00)80493-6. PMID 9655500. S2CID 10915358.
• Kinoshita A, Kinoshita M, Akiyama H, Tomimoto H, Akiguchi I, Kumar S, Noda M, Kimura J (November 1998). "Identification of septins in neurofibrillary tangles in Alzheimer's disease". The American Journal of Pathology. 153 (5): 1551–60. doi:10.1016/S0002-9440(10)65743-4. PMC 1853406. PMID 9811347.
• Sanger Centre, The; Washington University Genome Sequencing Cente, The (November 1998). "Toward a complete human genome sequence". Genome Research. 8 (11): 1097–108. doi:10.1101/gr.8.11.1097. PMID 9847074.
• Beites CL, Xie H, Bowser R, Trimble WS (May 1999). "The septin CDCrel-1 binds syntaxin and inhibits exocytosis". Nature Neuroscience. 2 (5): 434–9. doi:10.1038/8100. PMID 10321247. S2CID 5863477.
• Hoja MR, Wahlestedt C, Höög C (August 2000). "A visual intracellular classification strategy for uncharacterized human proteins". Experimental Cell Research. 259 (1): 239–46. doi:10.1006/excr.2000.4948. PMID 10942595.
• Sakai K, Kurimoto M, Tsugu A, Hubbard SL, Trimble WS, Rutka JT (May 2002). "Expression of Nedd5, a mammalian septin, in human brain tumors". Journal of Neuro-Oncology. 57 (3): 169–77. doi:10.1023/A:1015721801075. PMID 12125979. S2CID 20554212.
• Surka MC, Tsang CW, Trimble WS (October 2002). "The mammalian septin MSF localizes with microtubules and is required for completion of cytokinesis". Molecular Biology of the Cell. 13 (10): 3532–45. doi:10.1091/mbc.E02-01-0042. PMC 129964. PMID 12388755.
• Sheffield PJ, Oliver CJ, Kremer BE, Sheng S, Shao Z, Macara IG (January 2003). "Borg/septin interactions and the assembly of mammalian septin heterodimers, trimers, and filaments". The Journal of Biological Chemistry. 278 (5): 3483–8. doi:10.1074/jbc.M209701200. PMID 12446710.
• Vega IE, Hsu SC (January 2003). "The septin protein Nedd5 associates with both the exocyst complex and microtubules and disruption of its GTPase activity promotes aberrant neurite sprouting in PC12 cells". NeuroReport. 14 (1): 31–7. doi:10.1097/00001756-200301200-00006. PMID 12544826. S2CID 22757290.
• Koshelev YA, Kiselev SL, Georgiev GP (2004). "Interaction of the S100A4 (Mts1) protein with septins Sept2, Sept6, and Sept7 in vitro". Doklady Biochemistry and Biophysics. 391: 195–7. doi:10.1023/A:1025149005902. PMID 14531065. S2CID 26291196.
• She YM, Huang YW, Zhang L, Trimble WS (2004). "Septin 2 phosphorylation: theoretical and mass spectrometric evidence for the existence of a single phosphorylation site in vivo". Rapid Communications in Mass Spectrometry. 18 (10): 1123–30. Bibcode:2004RCMS...18.1123S. doi:10.1002/rcm.1453. PMID 15150837.
• Nagata K, Asano T, Nozawa Y, Inagaki M (December 2004). "Biochemical and cell biological analyses of a mammalian septin complex, Sept7/9b/11". The Journal of Biological Chemistry. 279 (53): 55895–904. doi:10.1074/jbc.M406153200. PMID 15485874.
• Rush J, Moritz A, Lee KA, Guo A, Goss VL, Spek EJ, Zhang H, Zha XM, Polakiewicz RD, Comb MJ (January 2005). "Immunoaffinity profiling of tyrosine phosphorylation in cancer cells". Nature Biotechnology. 23 (1): 94–101. doi:10.1038/nbt1046. PMID 15592455. S2CID 7200157.
• Andersen JS, Lam YW, Leung AK, Ong SE, Lyon CE, Lamond AI, Mann M (January 2005). "Nucleolar proteome dynamics". Nature. 433 (7021): 77–83. Bibcode:2005Natur.433...77A. doi:10.1038/nature03207. PMID 15635413. S2CID 4344740.
• Spiliotis ET, Kinoshita M, Nelson WJ (March 2005). "A mitotic septin scaffold required for Mammalian chromosome congression and segregation". Science. 307 (5716): 1781–5. Bibcode:2005Sci...307.1781S. doi:10.1126/science.1106823. PMC 3368603. PMID 15774761.