SEPSECS

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O-phosphoseryl-tRNA(Sec) selenium transferase is an enzyme that in humans is encoded by the SEPSECS gene.^[5]^[6]^[7]^[8]^[9]

SEPSECS

Available structures

Ortholog search: PDBe RCSB

List of PDB id codes
3HL2, 4ZDO, 4ZDL, 4ZDP

Identifiers

SEPSECS, LP, PCH2D, SLA, SLA/LP, Sep (O-phosphoserine) tRNA:Sec (selenocysteine) tRNA synthase, soluble liver antigen, SecS

External IDs

OMIM: 613009; MGI: 1098791; HomoloGene: 15031; GeneCards: SEPSECS; OMA:SEPSECS - orthologs

Gene location (Human)

Chr.	Chromosome 4 (human)^[1]

Band	4p15.2	Start	25,120,014 bp^[1]
Band	4p15.2	End	25,160,550 bp^[1]

Gene location (Mouse)

Chr.	Chromosome 5 (mouse)^[2]

Band	5 C1\|5 28.44 cM	Start	52,797,429 bp^[2]
Band	5 C1\|5 28.44 cM	End	52,827,050 bp^[2]

RNA expression pattern

Human

Mouse (ortholog)

Top expressed in

mucosa of ileum

testicle

right lobe of liver

jejunal mucosa

gonad

Achilles tendon

body of pancreas

pancreatic epithelial cell

rectum

gastric mucosa

Top expressed in

muscle of thorax

islet of Langerhans

left lobe of liver

thyroid cartilage

spermatocyte

secondary oocyte

right kidney

renal pelvis

Ileal epithelium

zygote

More reference expression data

n/a

Gene ontology
Molecular function	transferase activity tRNA binding selenotransferase activity catalytic activity protein binding RNA binding phosphoseryl-selenocysteinyl-tRNA selenium transferase activity
Cellular component	cytoplasm cytosol nucleus
Biological process	selenocysteine incorporation protein biosynthesis selenocysteine metabolic process selenocysteinyl-tRNA(Sec) biosynthetic process
Sources:Amigo / QuickGO

Species

Human

Mouse


51091


211006


ENSG00000109618


ENSMUSG00000029173


Q9HD40


Q6P6M7

RefSeq (mRNA)


NM_001159728 NM_016955


NM_172490 NM_001363463

RefSeq (protein)


NP_058651


NP_766078 NP_001350392

Location (UCSC)

Chr 4: 25.12 – 25.16 Mb

Chr 5: 52.8 – 52.83 Mb

PubMed search

^[3]

^[4]

View/Edit Human

View/Edit Mouse

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000109618 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000029173 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Xu XM, Mix H, Carlson BA, Grabowski PJ, Gladyshev VN, Berry MJ, Hatfield DL (Dec 2005). "Evidence for direct roles of two additional factors, SECp43 and soluble liver antigen, in the selenoprotein synthesis machinery". J. Biol. Chem. 280 (50): 41568–75. doi:10.1074/jbc.M506696200. PMID 16230358.
^ Costa M, Rodríguez-Sánchez JL, Czaja AJ, Gelpí C (Aug 2000). "Isolation and characterization of cDNA encoding the antigenic protein of the human tRNP(Ser)Sec complex recognized by autoantibodies from patients with type-1 autoimmune hepatitis". Clin. Exp. Immunol. 121 (2): 364–74. doi:10.1046/j.1365-2249.2000.01280.x. PMC 1905695. PMID 10931155.
^ Yuan J, Palioura S, Salazar JC, Su D, O'Donoghue P, Hohn MJ, Cardoso AM, Whitman WB, Söll D (Dec 2006). "RNA-dependent conversion of phosphoserine forms selenocysteine in eukaryotes and archaea". Proc. Natl. Acad. Sci. U.S.A. 103 (50): 18923–7. Bibcode:2006PNAS..10318923Y. doi:10.1073/pnas.0609703104. PMC 1748153. PMID 17142313.
^ Xu XM, Carlson BA, Mix H, Zhang Y, Saira K, Glass RS, Berry MJ, Gladyshev VN, Hatfield DL (Apr 2007). "Biosynthesis of selenocysteine on its tRNA in eukaryotes". PLOS Biol. 5 (1): e4. doi:10.1371/journal.pbio.0050004. PMC 1717018. PMID 17194211.
^ "Entrez Gene: SLA/LP soluble liver antigen/liver pancreas antigen".

Further reading

Herkel J, Heidrich B, Nieraad N, Wies I, Rother M, Lohse AW (2002). "Fine specificity of autoantibodies to soluble liver antigen and liver/pancreas". Hepatology. 35 (2): 403–8. doi:10.1053/jhep.2002.30699. PMID 11826415. S2CID 46400743.
Volkmann M, Martin L, Bäurle A, Heid H, Strassburg CP, Trautwein C, Fiehn W, Manns MP (2001). "Soluble liver antigen: isolation of a 35-kd recombinant protein (SLA-p35) specifically recognizing sera from patients with autoimmune hepatitis". Hepatology. 33 (3): 591–6. doi:10.1053/jhep.2001.22218. PMID 11230739. S2CID 11978013.
Wies I, Brunner S, Henninger J, Herkel J, Kanzler S, Meyer zum Büschenfelde KH, Lohse AW (2000). "Identification of target antigen for SLA/LP autoantibodies in autoimmune hepatitis". Lancet. 355 (9214): 1510–5. doi:10.1016/S0140-6736(00)02166-8. PMID 10801173. S2CID 45159673.

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