Selenoprotein T , also known as SELT , is a protein that in humans is encoded by the SELT gene .[ 5] [ 6] [ 7]
The selenocysteine is encoded by the UGA codon that normally signals translation termination. The 3' UTR of selenoprotein genes have a common stem-loop structure, the sec insertion sequence (SECIS), that is necessary for the recognition of UGA as a Sec codon rather than as a stop signal.[ 7]
Selenoprotein T contains a selenocysteine (Sec) residue at its active site.
^ a b c GRCh38: Ensembl release 89: ENSG00000198843 – Ensembl , May 2017^ a b c GRCm38: Ensembl release 89: ENSMUSG00000075700 – Ensembl , May 2017^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ Kryukov GV, Kryukov VM, Gladyshev VN (November 1999). "New mammalian selenocysteine-containing proteins identified with an algorithm that searches for selenocysteine insertion sequence elements" . J. Biol. Chem . 274 (48): 33888–97. doi :10.1074/jbc.274.48.33888 PMID 10567350 . ^ Kryukov GV, Castellano S, Novoselov SV, Lobanov AV, Zehtab O, Guigó R, Gladyshev VN (May 2003). "Characterization of mammalian selenoproteomes" . Science . 300 (5624): 1439–43. Bibcode :2003Sci...300.1439K . doi :10.1126/science.1083516 . PMID 12775843 . S2CID 10363908 . ^ a b "Entrez Gene: SELT selenoprotein T" .
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