Syndecan-2

Syndecan-2 is a protein that in humans is encoded by the SDC2 gene.

SDC2
Identifiers
Aliases	SDC2, CD362, HSPG, HSPG1, SYND2, syndecan 2
External IDs	OMIM: 142460; MGI: 1349165; HomoloGene: 2253; GeneCards: SDC2; OMA:SDC2 - orthologs
Gene location (Human) Chr. Chromosome 8 (human) Band 8q22.1 Start 96,493,813 bp End 96,611,790 bp
Gene location (Mouse) Chr. Chromosome 15 (mouse) Band 15 B3.1|15 13.74 cM Start 32,920,869 bp End 33,035,081 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in tibia Achilles tendon synovial joint retinal pigment epithelium left lobe of thyroid gland right coronary artery right lobe of thyroid gland popliteal artery tibial arteries Descending thoracic aorta Top expressed in epithelium of lens vestibular sensory epithelium calvaria body of femur ciliary body iris ankle retinal pigment epithelium left lobe of liver pituitary gland More reference expression data BioGPS More reference expression data
Gene ontology Molecular function PDZ domain binding protein binding identical protein binding Cellular component integral component of membrane membrane plasma membrane lysosomal lumen Golgi lumen endoplasmic reticulum lumen cell surface extracellular matrix collagen-containing extracellular matrix Biological process glycosaminoglycan metabolic process cell differentiation ephrin receptor signaling pathway nervous system development retinoid metabolic process regulation of dendrite morphogenesis bioluminescence glycosaminoglycan catabolic process glycosaminoglycan biosynthetic process leukocyte migration post-translational protein modification cell migration dendrite morphogenesis biological process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 6383 15529 Ensembl ENSG00000169439 ENSMUSG00000022261 UniProt P34741 P43407 RefSeq (mRNA) NM_002998 NM_008304 RefSeq (protein) NP_002989 NP_032330 Location (UCSC) Chr 8: 96.49 – 96.61 Mb Chr 15: 32.92 – 33.04 Mb PubMed search
Wikidata
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Function

The protein encoded by this gene is a transmembrane (type I) heparan sulfate proteoglycan and is a member of the syndecan proteoglycan family. The syndecans mediate cell binding, cell signaling, and cytoskeletal organization and syndecan receptors are required for internalization of the HIV-1 tat protein. The syndecan-2 protein functions as an integral membrane protein and participates in cell proliferation, cell migration and cell-matrix interactions via its receptor for extracellular matrix proteins. Altered syndecan-2 expression has been detected in several different tumor types.

Interactions

SDC2 has been shown to interact with:

• CASK,
• Laminin, alpha 3, and
• EZR

Further reading

• Mahley RW, Ji ZS (1999). "Remnant lipoprotein metabolism: key pathways involving cell-surface heparan sulfate proteoglycans and apolipoprotein E." J. Lipid Res. 40 (1): 1–16. doi:10.1016/S0022-2275(20)33334-4. PMID 9869645.
• Labarrere CA, Pitts D, Halbrook H, Faulk WP (1992). "Natural anticoagulant pathways in normal and transplanted human hearts". J. Heart Lung Transplant. 11 (2 Pt 1): 342–7. PMID 1315572.
• Marynen P, Zhang J, Cassiman JJ, Van den Berghe H, David G (1989). "Partial primary structure of the 48- and 90-kilodalton core proteins of cell surface-associated heparan sulfate proteoglycans of lung fibroblasts. Prediction of an integral membrane domain and evidence for multiple distinct core proteins at the cell surface of human lung fibroblasts". J. Biol. Chem. 264 (12): 7017–24. doi:10.1016/S0021-9258(18)83534-7. PMID 2523388.
• Sage H, Vernon RB, Funk SE, Everitt EA, Angello J (1989). "SPARC, a secreted protein associated with cellular proliferation, inhibits cell spreading in vitro and exhibits Ca+2-dependent binding to the extracellular matrix". J. Cell Biol. 109 (1): 341–56. doi:10.1083/jcb.109.1.341. PMC 2115491. PMID 2745554.
• Lories V, De Boeck H, David G, Cassiman JJ, Van den Berghe H (1987). "Heparan sulfate proteoglycans of human lung fibroblasts. Structural heterogeneity of the core proteins of the hydrophobic cell-associated forms". J. Biol. Chem. 262 (2): 854–9. doi:10.1016/S0021-9258(19)75865-7. PMID 2948951.
• Brown KJ, Parish CR (1994). "Histidine-rich glycoprotein and platelet factor 4 mask heparan sulfate proteoglycans recognized by acidic and basic fibroblast growth factor". Biochemistry. 33 (46): 13918–27. doi:10.1021/bi00250a047. PMID 7524669.
• Bolton P, Powell J, Rutter M, Buckle V, Yates JR, Ishikawa-Brush Y, Monaco AP (1995). "Autism, mental retardation, multiple exostoses and short stature in a female with 46,X,t(X;8)(p22.13;q22.1)". Psychiatr. Genet. 5 (2): 51–5. doi:10.1097/00041444-199522000-00001. PMID 7551962. S2CID 45132642.
• Barillari G, Gendelman R, Gallo RC, Ensoli B (1993). "The Tat protein of human immunodeficiency virus type 1, a growth factor for AIDS Kaposi sarcoma and cytokine-activated vascular cells, induces adhesion of the same cell types by using integrin receptors recognizing the RGD amino acid sequence". Proc. Natl. Acad. Sci. U.S.A. 90 (17): 7941–5. Bibcode:1993PNAS...90.7941B. doi:10.1073/pnas.90.17.7941. PMC 47263. PMID 7690138.
• Lyon M, Deakin JA, Mizuno K, Nakamura T, Gallagher JT (1994). "Interaction of hepatocyte growth factor with heparan sulfate. Elucidation of the major heparan sulfate structural determinants". J. Biol. Chem. 269 (15): 11216–23. doi:10.1016/S0021-9258(19)78113-7. PMID 8157651.
• Albini A, Benelli R, Presta M, Rusnati M, Ziche M, Rubartelli A, Paglialunga G, Bussolino F, Noonan D (1996). "HIV-tat protein is a heparin-binding angiogenic growth factor". Oncogene. 12 (2): 289–97. PMID 8570206.
• Soussi-Yanicostas N, Hardelin JP, Arroyo-Jimenez MM, Ardouin O, Legouis R, Levilliers J, Traincard F, Betton JM, Cabanié L, Petit C (1997). "Initial characterization of anosmin-1, a putative extracellular matrix protein synthesized by definite neuronal cell populations in the central nervous system". J. Cell Sci. 109 (7): 1749–57. doi:10.1242/jcs.109.7.1749. PMID 8832397.
• Christa L, Carnot F, Simon MT, Levavasseur F, Stinnakre MG, Lasserre C, Thepot D, Clement B, Devinoy E, Brechot C (1997). "HIP/PAP is an adhesive protein expressed in hepatocarcinoma, normal Paneth, and pancreatic cells". Am. J. Physiol. 271 (6 Pt 1): G993–1002. doi:10.1152/ajpgi.1996.271.6.G993. PMID 8997243.
• Rusnati M, Coltrini D, Oreste P, Zoppetti G, Albini A, Noonan D, d'Adda di Fagagna F, Giacca M, Presta M (1997). "Interaction of HIV-1 Tat protein with heparin. Role of the backbone structure, sulfation, and size". J. Biol. Chem. 272 (17): 11313–20. doi:10.1074/jbc.272.17.11313. PMID 9111037.
• Oh ES, Couchman JR, Woods A (1997). "Serine phosphorylation of syndecan-2 proteoglycan cytoplasmic domain". Arch. Biochem. Biophys. 344 (1): 67–74. doi:10.1006/abbi.1997.0180. PMID 9244383.
• Ishikawa-Brush Y, Powell JF, Bolton P, Miller AP, Francis F, Willard HF, Lehrach H, Monaco AP (1997). "Autism and multiple exostoses associated with an X;8 translocation occurring within the GRPR gene and 3' to the SDC2 gene". Hum. Mol. Genet. 6 (8): 1241–50. doi:10.1093/hmg/6.8.1241. PMID 9259269.
• Chang HC, Samaniego F, Nair BC, Buonaguro L, Ensoli B (1997). "HIV-1 Tat protein exits from cells via a leaderless secretory pathway and binds to extracellular matrix-associated heparan sulfate proteoglycans through its basic region". AIDS. 11 (12): 1421–31. doi:10.1097/00002030-199712000-00006. PMID 9342064. S2CID 7648619.
• Grootjans JJ, Zimmermann P, Reekmans G, Smets A, Degeest G, Dürr J, David G (1998). "Syntenin, a PDZ protein that binds syndecan cytoplasmic domains". Proc. Natl. Acad. Sci. U.S.A. 94 (25): 13683–8. doi:10.1073/pnas.94.25.13683. PMC 28366. PMID 9391086.
• Cohen AR, Woods DF, Marfatia SM, Walther Z, Chishti AH, Anderson JM, Wood DF (1998). "Human CASK/LIN-2 binds syndecan-2 and protein 4.1 and localizes to the basolateral membrane of epithelial cells". J. Cell Biol. 142 (1): 129–38. doi:10.1083/jcb.142.1.129. PMC 2133028. PMID 9660868.