SC-40 may refer to:
- ISO/IEC JTC 1/SC 40, a standardization subcommittee of the ISO/IEC JTC 1 on IT Service Management and IT Governance
- SC-40, a computer developed by Systems Concepts
- USS SC-40, a United States Navy submarine chaser commissioned in 1918 and sold in 1924
- Scandium-40 (Sc-40 or 40Sc), an isotope of scandium
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