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The abbreviation SAFC or S.A.F.C. may refer to:

  • Sunderland A.F.C., an English football (soccer) team competing in the English Football League (EFL).

Other uses in sport:

In business:

  • Sigma-Aldrich Fine Chemicals, a subdivision of Sigma-Aldrich, a supplier of chemical materials
  • The former Stock Exchange code for Safeco, an American insurance company

In media:

In science:

  • Solid Acid Fuel Cell, a type of Phosphoric acid fuel cell which uses a phosphate salt instead of liquid phosphoric acid as electrolyte.