Rough Creek may refer to:
- Rough Creek (Conasauga River tributary), a stream in Georgia
- Rough Creek (Missouri)
- Rough Creek (Idaho), a primary outflow of Rough Lake, in the White Cloud Mountains Custer County, Idaho
- Rough Creek, an historical name of the Rough River in west-central Kentucky
- Rough Creek (Paluxy River tributary), stream in Texas
This disambiguation page lists articles about distinct geographical locations with the same name.
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