Rofleponide

Rofleponide
Clinical data
Other names	6α,9α-Difluoro-11β,16α,17α,21-tetrahydroxypregn-4-ene-3,20-dione, cyclic (R)-16,17-acetal with butyraldehyde; 16α,17α-[(1R)-butylidenebis(oxy)]-6α,9α-difluoro-11β,21-dihydroxypregn-4-ene-3,20-dione
Drug class	Corticosteroid; Glucocorticoid
Identifiers
	IUPAC name (4aS,4bR,5S,6aS,6bS,8R,9aR,10aS,10bS,12S)-4b,12-Difluoro-6b-glycoloyl-5-hydroxy-4a,6a-dimethyl-8-propyl-3,4,4a,4b,5,6,6a,6b,9a,10,10a,10b,11,12-tetradecahydro-2H-naphtho[2',1':4,5]indeno[1,2-d][1,3]dioxol-2-one;
CAS Number	144459-70-1;
PubChem CID	3055174;
ChemSpider	2316734;
UNII	R9IQ7GVL3E;
CompTox Dashboard (EPA)	DTXSID601318252 ;
Chemical and physical data
Formula	C25H34F2O6
Molar mass	468.538 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES CCC[C@@H]1O[C@@H]2C[C@H]3[C@@H]4C[C@@H](C5=CC(=O)CC[C@@]5([C@]4([C@H](C[C@@]3([C@@]2(O1)C(=O)CO)C)O)F)C)F;
	InChI InChI=1S/C25H34F2O6/c1-4-5-21-32-20-10-14-15-9-17(26)16-8-13(29)6-7-22(16,2)24(15,27)18(30)11-23(14,3)25(20,33-21)19(31)12-28/h8,14-15,17-18,20-21,28,30H,4-7,9-12H2,1-3H3/t14-,15-,17-,18-,20+,21+,22-,23-,24-,25+/m0/s1; Key:IXTCZMJQGGONPY-XJAYAHQCSA-N;

Rofleponide is a synthetic glucocorticoid corticosteroid which was never marketed.^[1]^[2]^[3]^[4]

References

^ "Rofleponide". AdisInsight.
^ Ahlström-Emanuelsson C, Andersson M, Persson C, Schrewelius C, Greiff L (2004). "Topical treatment with aqueous solutions of rofleponide palmitate and budesonide in a pollen-season model of allergic rhinitis". Clin. Exp. Allergy. 34 (5): 731–5. doi:10.1111/j.1365-2222.2004.1965.x. PMID 15144464. S2CID 1480600.
^ K Nagaraju (30 November 2013). Manual of Pediatric Allergy. JP Medical Ltd. pp. 109–. ISBN 978-93-5090-498-5.
^ Jonathan A. Bernstein (27 May 2016). Rhinitis, An Issue of Immunology and Allergy Clinics of North America, E-Book. Elsevier Health Sciences. pp. 407–. ISBN 978-0-323-44468-2.

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