Ro20-8065

Ro20-8065
Legal status
Legal status	CA: Schedule IV; DE: NpSG (Industrial and scientific use only); UK: Under Psychoactive Substances Act;
Identifiers
	IUPAC name 7,8-dichloro-5-(2-fluorophenyl)-1,3-dihydro-1,4-benzodiazepin-2-one;
CAS Number	88695-06-1;
PubChem CID	10358803;
ChemSpider	8534252;
ChEMBL	ChEMBL443823;
CompTox Dashboard (EPA)	DTXSID50877921 ;
Chemical and physical data
Formula	C15H9Cl2FN2O
Molar mass	323.15 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES C1C(=O)NC2=CC(=C(C=C2C(=N1)C3=CC=CC=C3F)Cl)Cl;
	InChI InChI=1S/C15H9Cl2FN2O/c16-10-5-9-13(6-11(10)17)20-14(21)7-19-15(9)8-3-1-2-4-12(8)18/h1-6H,7H2,(H,20,21); Key:XINLNKMOSCQFJB-UHFFFAOYSA-N;

Ro20-8065 (8-Chloronorflurazepam) is a benzodiazepine derivative with anticonvulsant and muscle relaxant effects,^[1] which has been sold as a designer drug.^[2]

References

^ Zhang W, Koehler KF, Harris B, Skolnick P, Cook JM (March 1994). "Synthesis of benzo-fused benzodiazepines employed as probes of the agonist pharmacophore of benzodiazepine receptors". Journal of Medicinal Chemistry. 37 (6): 745–57. doi:10.1021/jm00032a007. PMID 8145224.
^ Catalani V, Botha M, Corkery JM, Guirguis A, Vento A, Scherbaum N, Schifano F (July 2021). "The Psychonauts' Benzodiazepines; Quantitative Structure-Activity Relationship (QSAR) Analysis and Docking Prediction of Their Biological Activity". Pharmaceuticals (Basel, Switzerland). 14 (8): 720. doi:10.3390/ph14080720. PMC 8398354. PMID 34451817.

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Legal status

Legal status	CA: Schedule IV DE: NpSG (Industrial and scientific use only) UK: Under Psychoactive Substances Act
Identifiers
IUPAC name 7,8-dichloro-5-(2-fluorophenyl)-1,3-dihydro-1,4-benzodiazepin-2-one
CAS Number	88695-06-1
PubChem CID	10358803
ChemSpider	8534252
ChEMBL	ChEMBL443823
CompTox Dashboard (EPA)	DTXSID50877921
Chemical and physical data
Formula	C₁₅H₉Cl₂FN₂O
Molar mass	323.15 g·mol⁻¹
3D model (JSmol)	Interactive image
SMILES C1C(=O)NC2=CC(=C(C=C2C(=N1)C3=CC=CC=C3F)Cl)Cl
InChI InChI=1S/C15H9Cl2FN2O/c16-10-5-9-13(6-11(10)17)20-14(21)7-19-15(9)8-3-1-2-4-12(8)18/h1-6H,7H2,(H,20,21) Key:XINLNKMOSCQFJB-UHFFFAOYSA-N