Region 4 or Region IV can refer to:
- One of the DVD region codes
- Region 4, Northwest Territories (Canadian census)
- The West of the US (one of four regions of the US census)
- One of the health regions of Canada managed by Vitalité Health Network
- Former Region 4 (Johannesburg), an administrative district in the city of Johannesburg, South Africa, from 2000 to 2006
- One of the Regions of Iran
- Coquimbo Region, Chile
- Southern Tagalog, Philippines
- Calabarzon, Philippines
This disambiguation page lists articles associated with the title Region 4.
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