Region 3 or Region III can refer to:
- One of the DVD region codes
- Region 3, Northwest Territories (Canadian census)
- The South of the US (American census)
- One of health regions of Canada managed by Horizon Health Network
- Former Region 3 (Johannesburg), an administrative district in the city of Johannesburg, South Africa, from 2000 to 2006
- One of Regions of Iran, commonly known as Azerbaijan (Iran)
- Atacama Region, Chile
- Central Luzon, Philippines
This disambiguation page lists articles associated with the title Region 3.
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