Randal MacDonnell or McDonnell may refer to:
- Randal MacDonnell, 1st Earl of Antrim (died 1636), son of Sorley Boy MacDonnell
- Randal MacDonnell, 1st Marquess of Antrim (1645 creation) (1609–1683), son of the 1st Earl of Antrim
- Randal MacDonnell, 1st Marquess of Antrim (1789 creation), Earl of Antrim
- Randal MacDonnell, 4th Earl of Antrim (1680–1721), Irish aristocrat
- Randal McDonnell, 8th Earl of Antrim (1911–1977), diplomat, activist, soldier and administrator from Northern Ireland
- Randal McDonnell, 10th Earl of Antrim (born 1967), Scottish landowner