Reticulon-1 also known as neuroendocrine-specific protein (NSP) is a protein that in humans is encoded by the RTN1 gene.[5][6]

RTN1
Identifiers
AliasesRTN1, NSP, reticulon 1
External IDsOMIM: 600865; MGI: 1933947; HomoloGene: 49654; GeneCards: RTN1; OMA:RTN1 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001243115
NM_021136
NM_206852
NM_206857
NM_001363702

NM_001007596
NM_001286448
NM_153457

RefSeq (protein)

NP_066959
NP_996734
NP_001350631

NP_001007597
NP_001273377
NP_703187

Location (UCSC)Chr 14: 59.6 – 59.87 MbChr 12: 72.26 – 72.46 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

This gene belongs to the family of reticulon-encoding genes. Reticulons are associated with the endoplasmic reticulum, and are involved in neuroendocrine secretion or in membrane trafficking in neuroendocrine cells. Alternatively spliced transcript variants encoding different isoforms have been identified. Multiple promoters rather than alternative splicing of internal exons seem to be involved in this diversity.[6]

Interactions

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RTN1 has been shown to interact with BCL2-like 1[7] and UGCG.[8]

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000139970Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000021087Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Kools PF, Roebroek AJ, Van de Velde HJ, Marynen P, Bullerdiek J, Van de Ven WJ (February 1994). "Regional mapping of the human NSP gene to chromosome region 14q21→q22 by fluorescence in situ hybridization analysis". Cytogenet Cell Genet. 66 (1): 48–50. doi:10.1159/000133662. PMID 8275708.
  6. ^ a b "Entrez Gene: RTN1 reticulon 1".
  7. ^ Tagami S, Eguchi Y, Kinoshita M, Takeda M, Tsujimoto Y (November 2000). "A novel protein, RTN-XS, interacts with both Bcl-XL and Bcl-2 on endoplasmic reticulum and reduces their anti-apoptotic activity". Oncogene. 19 (50): 5736–46. doi:10.1038/sj.onc.1203948. PMID 11126360.
  8. ^ Di Sano F, Fazi B, Citro G, Lovat PE, Cesareni G, Piacentini M (July 2003). "Glucosylceramide synthase and its functional interaction with RTN-1C regulate chemotherapeutic-induced apoptosis in neuroepithelioma cells". Cancer Res. 63 (14): 3860–5. PMID 12873973.

Further reading

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