Ribosomal protein S6 kinase alpha-2 is an enzyme that in humans is encoded by the RPS6KA2 gene .[ 5] [ 6]
RPS6KA2 Identifiers Aliases RPS6KA2 External IDs OMIM : 601685 ; MGI : 1342290 ; HomoloGene : 100680 ; GeneCards : RPS6KA2 ; OMA :RPS6KA2 - orthologs RNA expression patternBgee Human Mouse (ortholog)Top expressed in inferior olivary nucleus lower lobe of lung internal globus pallidus dorsal motor nucleus of vagus nerve inferior ganglion of vagus nerve C1 segment optic nerve right lung corpus callosum superior vestibular nucleus
Top expressed in granulocyte muscle of thigh neural layer of retina tail of embryo superior frontal gyrus dentate gyrus of hippocampal formation granule cell primary visual cortex genital tubercle lens ventricular zone
More reference expression data
BioGPS
Wikidata
This gene encodes a member of the RSK (ribosomal S6 kinase) family of serine and threonine kinases . This kinase contains 2 non-identical kinase catalytic domains and phosphorylates various substrates, including members of the mitogen -activated kinase (MAPK) signalling pathway. The activity of this protein has been implicated in controlling cell growth and differentiation . Alternate transcriptional splice variants, encoding different isoforms , have been characterized.[ 6]
^ a b c GRCh38: Ensembl release 89: ENSG00000071242 – Ensembl , May 2017^ a b c GRCm38: Ensembl release 89: ENSMUSG00000023809 – Ensembl , May 2017^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ Moller DE, Xia CH, Tang W, Zhu AX, Jakubowski M (Apr 1994). "Human rsk isoforms: cloning and characterization of tissue-specific expression". Am J Physiol . 266 (2 Pt 1): C351–9. doi :10.1152/ajpcell.1994.266.2.C351 . PMID 8141249 . ^ a b "Entrez Gene: RPS6KA2 ribosomal protein S6 kinase, 90kDa, polypeptide 2" .^ a b Roux PP, Richards Stephanie A, Blenis John (Jul 2003). "Phosphorylation of p90 Ribosomal S6 Kinase (RSK) Regulates Extracellular Signal-Regulated Kinase Docking and RSK Activity" . Mol. Cell. Biol . 23 (14). United States: 4796–804. doi :10.1128/MCB.23.14.4796-4804.2003 . ISSN 0270-7306 . PMC 162206 PMID 12832467 . ^ a b Zhao Y, Bjorbaek C, Moller D E (Nov 1996). "Regulation and interaction of pp90(rsk) isoforms with mitogen-activated protein kinases" . J. Biol. Chem . 271 (47). UNITED STATES: 29773–9. doi :10.1074/jbc.271.47.29773 ISSN 0021-9258 . PMID 8939914 .
Dawson SJ, White LA (1992). "Treatment of Haemophilus aphrophilus endocarditis with ciprofloxacin". J. Infect . 24 (3): 317–20. doi :10.1016/S0163-4453(05)80037-4 . PMID 1602151 . Zhao Y, Bjørbaek C, Weremowicz S, et al. (1995). "RSK3 encodes a novel pp90rsk isoform with a unique N-terminal sequence: growth factor-stimulated kinase function and nuclear translocation" . Mol. Cell. Biol . 15 (8): 4353–63. doi :10.1128/MCB.15.8.4353 . PMC 230675 PMID 7623830 . Wong EV, Schaefer AW, Landreth G, Lemmon V (1996). "Involvement of p90rsk in neurite outgrowth mediated by the cell adhesion molecule L1" . J. Biol. Chem . 271 (30): 18217–23. doi :10.1074/jbc.271.30.18217 PMID 8663493 . Xing J, Ginty DD, Greenberg ME (1996). "Coupling of the RAS-MAPK pathway to gene activation by RSK2, a growth factor-regulated CREB kinase". Science . 273 (5277): 959–63. Bibcode :1996Sci...273..959X . doi :10.1126/science.273.5277.959 . PMID 8688081 . S2CID 22226803 . Zhao Y, Bjorbaek C, Moller DE (1997). "Regulation and interaction of pp90(rsk) isoforms with mitogen-activated protein kinases" . J. Biol. Chem . 271 (47): 29773–9. doi :10.1074/jbc.271.47.29773 PMID 8939914 . Fukunaga R, Hunter T (1997). "MNK1, a new MAP kinase-activated protein kinase, isolated by a novel expression screening method for identifying protein kinase substrates" . EMBO J . 16 (8): 1921–33. doi :10.1093/emboj/16.8.1921 . PMC 1169795 PMID 9155018 . del Peso L, González-García M, Page C, et al. (1997). "Interleukin-3-induced phosphorylation of BAD through the protein kinase Akt". Science . 278 (5338): 687–9. Bibcode :1997Sci...278..687D . doi :10.1126/science.278.5338.687 . PMID 9381178 . Deak M, Clifton AD, Lucocq LM, Alessi DR (1998). "Mitogen- and stress-activated protein kinase-1 (MSK1) is directly activated by MAPK and SAPK2/p38, and may mediate activation of CREB" . EMBO J . 17 (15): 4426–41. doi :10.1093/emboj/17.15.4426 . PMC 1170775 PMID 9687510 . Du K, Montminy M (1999). "CREB is a regulatory target for the protein kinase Akt/PKB" . J. Biol. Chem . 273 (49): 32377–9. doi :10.1074/jbc.273.49.32377 PMID 9829964 . Smith JA, Poteet-Smith CE, Malarkey K, Sturgill TW (1999). "Identification of an extracellular signal-regulated kinase (ERK) docking site in ribosomal S6 kinase, a sequence critical for activation by ERK in vivo" . J. Biol. Chem . 274 (5): 2893–8. doi :10.1074/jbc.274.5.2893 PMID 9915826 . Jensen CJ, Buch MB, Krag TO, et al. (1999). "90-kDa ribosomal S6 kinase is phosphorylated and activated by 3-phosphoinositide-dependent protein kinase-1" . J. Biol. Chem . 274 (38): 27168–76. doi :10.1074/jbc.274.38.27168 PMID 10480933 . Schimenti JC (2000). "ORFless, intronless, and mutant transcription units in the mouse t complex responder (Tcr) locus". Mamm. Genome . 10 (10): 969–76. doi :10.1007/s003359901142 . PMID 10501965 . S2CID 23157540 . Scheid MP, Schubert KM, Duronio V (1999). "Regulation of bad phosphorylation and association with Bcl-x(L) by the MAPK/Erk kinase" . J. Biol. Chem . 274 (43): 31108–13. doi :10.1074/jbc.274.43.31108 PMID 10521512 . Tan Y, Demeter MR, Ruan H, Comb MJ (2000). "BAD Ser-155 phosphorylation regulates BAD/Bcl-XL interaction and cell survival" . J. Biol. Chem . 275 (33): 25865–9. doi :10.1074/jbc.M004199200 PMID 10837486 . Lizcano JM, Morrice N, Cohen P (2001). "Regulation of BAD by cAMP-dependent protein kinase is mediated via phosphorylation of a novel site, Ser155" . Biochem. J . 349 (Pt 2): 547–57. doi :10.1042/0264-6021:3490547 . PMC 1221178 PMID 10880354 . Datta SR, Katsov A, Hu L, et al. (2000). "14-3-3 proteins and survival kinases cooperate to inactivate BAD by BH3 domain phosphorylation" . Mol. Cell . 6 (1): 41–51. doi :10.1016/S1097-2765(00)00006-X PMID 10949026 . Gudi T, Casteel DE, Vinson C, et al. (2001). "NO activation of fos promoter elements requires nuclear translocation of G-kinase I and CREB phosphorylation but is independent of MAP kinase activation". Oncogene . 19 (54): 6324–33. doi :10.1038/sj.onc.1204007 . PMID 11175347 . S2CID 20150481 . Willard FS, Crouch MF (2001). "MEK, ERK, and p90RSK are present on mitotic tubulin in Swiss 3T3 cells: a role for the MAP kinase pathway in regulating mitotic exit". Cell. Signal . 13 (9): 653–64. doi :10.1016/S0898-6568(01)00185-1 . PMID 11495723 . Schinelli S, Zanassi P, Paolillo M, et al. (2001). "Stimulation of endothelin B receptors in astrocytes induces cAMP response element-binding protein phosphorylation and c-fos expression via multiple mitogen-activated protein kinase signaling pathways" . J. Neurosci . 21 (22): 8842–53. doi :10.1523/JNEUROSCI.21-22-08842.2001 . PMC 6762276 PMID 11698596 .
