40S ribosomal protein S18 is a protein that in humans is encoded by the RPS18 gene .[5] [6] [7]
RPS18 Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4UG0 , 4V6X , 5A2Q , 5AJ0 , 4KZY , 3J7R , 4D61 , 4KZX , 4D5L , 4V5Z , 5FLX , 4UJD , 3J7P , 4KZZ , 4UJE , 4UJC
Identifiers Aliases RPS18 External IDs OMIM : 180473 MGI : 98146 HomoloGene : 88764 GeneCards : RPS18 Wikidata
Ribosomes , the organelles that catalyze protein synthesis , consist of a small 40S subunit and a large 60S subunit . Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 40S subunit. The protein belongs to the S13P family of ribosomal proteins. It is located in the cytoplasm . The gene product of the E. coli ortholog (ribosomal protein S13) is involved in the binding of fMet -tRNA, and thus, in the initiation of translation . This gene is an ortholog of mouse Ke3. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome.[7]
References
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^ a b c ENSG00000096150, ENSG00000231500, ENSG00000235650, ENSG00000223367, ENSG00000227794 GRCh38: Ensembl release 89: ENSG00000226225, ENSG00000096150, ENSG00000231500, ENSG00000235650, ENSG00000223367, ENSG00000227794 – Ensembl , May 2017^ a b c GRCm38: Ensembl release 89: ENSMUSG00000008668 – Ensembl , May 2017^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ Chassin D, Bellet D, Koman A (Mar 1993). "The human homolog of ribosomal protein S18" . Nucleic Acids Res . 21 (3): 745. doi :10.1093/nar/21.3.745 . PMC 309181 PMID 8441687 . ^ Kenmochi N, Kawaguchi T, Rozen S, Davis E, Goodman N, Hudson TJ, Tanaka T, Page DC (Aug 1998). "A map of 75 human ribosomal protein genes" . Genome Res . 8 (5): 509–23. doi :10.1101/gr.8.5.509 PMID 9582194 . ^ a b "Entrez Gene: RPS18 ribosomal protein S18" .
Further reading
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Wool IG, Chan YL, Glück A (1996). "Structure and evolution of mammalian ribosomal proteins". Biochem. Cell Biol . 73 (11–12): 933–47. doi :10.1139/o95-101 . PMID 8722009 . Chan YL, Paz V, Wool IG (1991). "The primary structure of rat ribosomal protein S18" . Biochem. Biophys. Res. Commun . 178 (3): 1212–8. doi :10.1016/0006-291X(91)91022-5 . PMC 335161 PMID 1872840 . Chassin D, Bénifla JL, Delattre C, et al. (1994). "Identification of genes overexpressed in tumors through preferential expression screening in trophoblasts". Cancer Res . 54 (19): 5217–23. PMID 7923143 . Vladimirov SN, Ivanov AV, Karpova GG, et al. (1996). "Characterization of the human small-ribosomal-subunit proteins by N-terminal and internal sequencing, and mass spectrometry" . Eur. J. Biochem . 239 (1): 144–9. doi :10.1111/j.1432-1033.1996.0144u.x PMID 8706699 . Andersen JS, Lyon CE, Fox AH, et al. (2002). "Directed proteomic analysis of the human nucleolus" . Curr. Biol . 12 (1): 1–11. Bibcode :2002CBio...12....1A . doi :10.1016/S0960-9822(01)00650-9 PMID 11790298 . S2CID 14132033 . Mishra-Gorur K, Singer HA, Castellot JJ (2002). "The S18 ribosomal protein is a putative substrate for Ca2+/calmodulin-activated protein kinase II" . J. Biol. Chem . 277 (37): 33537–40. doi :10.1074/jbc.C200342200 PMID 12145273 . Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences" . Proc. Natl. Acad. Sci. U.S.A . 99 (26): 16899–903. Bibcode :2002PNAS...9916899M . doi :10.1073/pnas.242603899 PMC 139241 PMID 12477932 . Mungall AJ, Palmer SA, Sims SK, et al. (2003). "The DNA sequence and analysis of human chromosome 6" . Nature . 425 (6960): 805–11. Bibcode :2003Natur.425..805M . doi :10.1038/nature02055 PMID 14574404 . Kusui K, Sasaki H, Adachi R, et al. (2005). "Ribosomal protein S18 identified as a cofilin-binding protein by using phage display library". Mol. Cell. Biochem . 262 (1–2): 187–93. doi :10.1023/B:MCBI.0000038234.35936.1c . PMID 15532723 . S2CID 30534195 . Andersen JS, Lam YW, Leung AK, et al. (2005). "Nucleolar proteome dynamics". Nature . 433 (7021): 77–83. Bibcode :2005Natur.433...77A . doi :10.1038/nature03207 . PMID 15635413 . S2CID 4344740 . Yu Y, Ji H, Doudna JA, Leary JA (2005). "Mass spectrometric analysis of the human 40S ribosomal subunit: native and HCV IRES-bound complexes" . Protein Sci . 14 (6): 1438–46. doi :10.1110/ps.041293005 . PMC 2253395 PMID 15883184 .
External links
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Overview of all the structural information available in the PDB for UniProt : P62269 PDBe-KB .
