ROBO2

Roundabout homolog 2 is a protein that in humans is encoded by the ROBO2 gene.

ROBO2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1UEM, 1UJT, 2EDJ
Identifiers
Aliases	ROBO2, SAX3, roundabout guidance receptor 2
External IDs	OMIM: 602431; MGI: 1890110; HomoloGene: 43188; GeneCards: ROBO2; OMA:ROBO2 - orthologs
Gene location (Human) Chr. Chromosome 3 (human) Band 3p12.3 Start 75,906,695 bp End 77,649,964 bp
Gene location (Mouse) Chr. Chromosome 16 (mouse) Band 16|16 C3.1 Start 73,688,727 bp End 74,208,713 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in ganglionic eminence ventricular zone buccal mucosa cell prefrontal cortex islet of Langerhans cartilage tissue Brodmann area 46 pons endothelial cell gonad Top expressed in Rostral migratory stream hand genital tubercle dentate gyrus of hippocampal formation granule cell superior frontal gyrus neural layer of retina ganglionic eminence primary visual cortex olfactory bulb superior colliculus More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding identical protein binding axon guidance receptor activity Cellular component integral component of membrane membrane cell surface axolemma extracellular exosome plasma membrane Biological process cell differentiation ureteric bud development kidney development negative regulation of synapse assembly Roundabout signaling pathway positive regulation of axonogenesis nervous system development multicellular organism development chemotaxis central nervous system development cellular response to hormone stimulus olfactory bulb interneuron development apoptotic process involved in luteolysis negative regulation of negative chemotaxis axon midline choice point recognition metanephros development homophilic cell adhesion via plasma membrane adhesion molecules retinal ganglion cell axon guidance brain development spinal cord development axon guidance outflow tract septum morphogenesis aortic valve morphogenesis pulmonary valve morphogenesis endocardial cushion formation positive regulation of Notch signaling pathway involved in heart induction aorta development ventricular septum morphogenesis Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 6092 268902 Ensembl ENSG00000185008 ENSMUSG00000052516 UniProt Q9HCK4 Q7TPD3 RefSeq (mRNA) NM_001128929 NM_001290039 NM_001290040 NM_001290065 NM_002942 NM_001378190 NM_001378191 NM_001378192 NM_001378193 NM_001378194 NM_001378195 NM_001378196 NM_001378197 NM_001378198 NM_001378199 NM_001378200 NM_001378201 NM_001378202 NM_001378203 NM_001394212 NM_001394213 NM_001394214 NM_001395656 NM_001395657 NM_175549 NM_001358490 NM_001358491 NM_001358492 NM_001358493 NM_001358494 RefSeq (protein) NP_001122401 NP_001276968 NP_001276969 NP_001276994 NP_002933 NP_001365119 NP_001365120 NP_001365121 NP_001365122 NP_001365123 NP_001365124 NP_001365125 NP_001365126 NP_001365127 NP_001365128 NP_001365129 NP_001365130 NP_001365131 NP_001365132 n/a Location (UCSC) Chr 3: 75.91 – 77.65 Mb Chr 16: 73.69 – 74.21 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

Further reading

• Hauptman G, Reichert MC, Abdal Rhida MA, Evans TA (December 2022). "Characterization of enhancer fragments in Drosophila robo2". Fly. 16 (1): 312–346. doi:10.1080/19336934.2022.2126259. PMC 9559326. PMID 36217698.
• Brose K, Bland KS, Wang KH, Arnott D, Henzel W, Goodman CS, et al. (March 1999). "Slit proteins bind Robo receptors and have an evolutionarily conserved role in repulsive axon guidance". Cell. 96 (6): 795–806. doi:10.1016/S0092-8674(00)80590-5. PMID 10102268. S2CID 16301178.
• Nguyen Ba-Charvet KT, Brose K, Marillat V, Kidd T, Goodman CS, Tessier-Lavigne M, et al. (March 1999). "Slit2-Mediated chemorepulsion and collapse of developing forebrain axons". Neuron. 22 (3): 463–473. doi:10.1016/S0896-6273(00)80702-3. PMID 10197527. S2CID 18663762.
• Nagase T, Kikuno R, Nakayama M, Hirosawa M, Ohara O (August 2000). "Prediction of the coding sequences of unidentified human genes. XVIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Research. 7 (4): 273–281. doi:10.1093/dnares/7.4.271. PMID 10997877.
• Nguyen Ba-Charvet KT, Brose K, Ma L, Wang KH, Marillat V, Sotelo C, et al. (June 2001). "Diversity and specificity of actions of Slit2 proteolytic fragments in axon guidance". The Journal of Neuroscience. 21 (12): 4281–4289. doi:10.1523/JNEUROSCI.21-12-04281.2001. PMC 6762758. PMID 11404413.
• Marillat V, Cases O, Nguyen-Ba-Charvet KT, Tessier-Lavigne M, Sotelo C, Chédotal A (January 2002). "Spatiotemporal expression patterns of slit and robo genes in the rat brain". The Journal of Comparative Neurology. 442 (2): 130–155. doi:10.1002/cne.10068. PMID 11754167. S2CID 24164570.
• Hivert B, Liu Z, Chuang CY, Doherty P, Sundaresan V (December 2002). "Robo1 and Robo2 are homophilic binding molecules that promote axonal growth". Molecular and Cellular Neurosciences. 21 (4): 534–545. doi:10.1006/mcne.2002.1193. PMID 12504588. S2CID 19664833.
• Grieshammer U, Plump AS, Wang F, Tessier-Lavigne M, Martin GR (May 2004). "SLIT2-mediated ROBO2 signaling restricts kidney induction to a single site". Developmental Cell. 6 (5): 709–717. doi:10.1016/S1534-5807(04)00108-X. PMID 15130495.
• Yue Y, Grossmann B, Galetzka D, Zechner U, Haaf T (December 2006). "Isolation and differential expression of two isoforms of the ROBO2/Robo2 axon guidance receptor gene in humans and mice". Genomics. 88 (6): 772–778. doi:10.1016/j.ygeno.2006.05.011. PMID 16829019.
• Lu W, van Eerde AM, Fan X, Quintero-Rivera F, Kulkarni S, Ferguson H, et al. (April 2007). "Disruption of ROBO2 is associated with urinary tract anomalies and confers risk of vesicoureteral reflux". American Journal of Human Genetics. 80 (4): 616–632. doi:10.1086/512735. PMC 1852714. PMID 17357069.