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Ribonuclease T2 is an enzyme that in humans is encoded by the RNASET2 gene.[5][6]

RNASET2
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesRNASET2, RNASE6PL, bA514O12.3, ribonuclease T2
External IDsOMIM: 612944 MGI: 3702087 HomoloGene: 31190 GeneCards: RNASET2
Gene location (Human)
Chromosome 6 (human)
Chr.Chromosome 6 (human)[1]
Chromosome 6 (human)
Genomic location for RNASET2
Genomic location for RNASET2
Band6q27Start166,929,504 bp[1]
End166,957,191 bp[1]
RNA expression pattern
PBB GE RNASET2 217983 s at fs.png

PBB GE RNASET2 gnf1h01557 at fs.png

PBB GE RNASET2 217984 at fs.png
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_003730

NM_026611
NM_029204

RefSeq (protein)

NP_003721

NP_080887
NP_001077407
NP_080887
NP_080887

Location (UCSC)Chr 6: 166.93 – 166.96 MbChr 17: 6.97 – 7.01 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

This ribonuclease gene is a novel member of the Rh/T2/S-glycoprotein class of extracellular ribonucleases. It is a single copy gene that maps to 6q27, a region associated with human malignancies and chromosomal rearrangement.[6]RNASET2 has been reported as a tumour associated antigen in anaplastic large cell lymphoma and other lymphomas.[7]

ReferencesEdit

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000026297 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000094724 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Trubia M, Sessa L, Taramelli R (Sep 1997). "Mammalian Rh/T2/S-glycoprotein ribonuclease family genes: cloning of a human member located in a region of chromosome 6 (6q27) frequently deleted in human malignancies". Genomics. 42 (2): 342–344. doi:10.1006/geno.1997.4679. PMID 9192857.
  6. ^ a b "Entrez Gene: RNASET2 ribonuclease T2".
  7. ^ Patel S, Chen H, Monti L, Gould E, Haralambieva E, Schmid J, Toomey D, Woessmann W, Roncador G, Hatton CS, Liggins AP, Taramelli R, Banham AH, Acquati F, Murphy D, Pulford K (Sep 2012). "RNASET2 - An autoantigen in anaplastic large cell lymphoma identified by protein array analysis". J Proteomics. 75 (17): 5279–5292. doi:10.1016/j.jprot.2012.06.009. PMID 22732457.

Further readingEdit