This ribonuclease gene is a novel member of the Rh/T2/S-glycoprotein class of extracellular ribonucleases. It is a single copy gene that maps to 6q27, a region associated with human malignancies and chromosomal rearrangement.RNASET2 has been reported as a tumour associated antigen in anaplastic large cell lymphoma and other lymphomas.
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Campomenosi P, Salis S, Lindqvist C, et al. (2006). "Characterization of RNASET2, the first human member of the Rh/T2/S family of glycoproteins". Arch. Biochem. Biophys. 449 (1–2): 17–26. doi:10.1016/j.abb.2006.02.022. PMID16620762.
Patel S, Chen H, Monti L, Gould E, Haralambieva E, Schmid J, Toomey D, Woessmann W, Roncador G, Hatton CS, Liggins AP, Taramelli R, Banham AH, Acquati F, Murphy D, Pulford K (2012). "RNASET2 - An autoantigen in anaplastic large cell lymphoma identified by protein array analysis". J Proteomics. 75 (17): 5279–5292. doi:10.1016/j.jprot.2012.06.009. PMID22732457.