RNF13

RING finger protein 13 is a protein that in humans is encoded by the RNF13 gene.

RNF13
Identifiers
Aliases	RNF13, RZF, ring finger protein 13, EIEE73, DEE73
External IDs	OMIM: 609247; MGI: 1346341; HomoloGene: 13493; GeneCards: RNF13; OMA:RNF13 - orthologs
Gene location (Human) Chr. Chromosome 3 (human) Band 3q25.1 Start 149,812,770 bp End 149,962,139 bp
Gene location (Mouse) Chr. Chromosome 3 (mouse) Band 3|3 D Start 57,643,483 bp End 57,742,654 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in corpus callosum Achilles tendon inferior ganglion of vagus nerve C1 segment subthalamic nucleus parotid gland optic nerve retinal pigment epithelium external globus pallidus pars reticulata Top expressed in retinal pigment epithelium deep cerebellar nuclei sciatic nerve globus pallidus iris pontine nuclei lateral geniculate nucleus ventral tegmental area ciliary body stroma of bone marrow More reference expression data BioGPS n/a
Gene ontology Molecular function metal ion binding protein binding ubiquitin protein ligase activity ubiquitin-protein transferase activity transferase activity zinc ion binding Cellular component integral component of membrane lysosomal membrane Golgi membrane nuclear inner membrane endosome lysosome Golgi apparatus endoplasmic reticulum membrane endoplasmic reticulum late endosome membrane nucleus membrane nucleoplasm cytosol intracellular membrane-bounded organelle Biological process protein ubiquitination protein autoubiquitination ubiquitin-dependent protein catabolic process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 11342 24017 Ensembl ENSG00000082996 ENSMUSG00000036503 UniProt O43567 O54965 RefSeq (mRNA) NM_007282 NM_183381 NM_183382 NM_183383 NM_183384 NM_001378285 NM_001378286 NM_001378287 NM_001378288 NM_001378289 NM_001378290 NM_001378291 NM_001113413 NM_011883 NM_001304454 NM_001304456 NM_001357080 RefSeq (protein) NP_009213 NP_899237 NP_899239 NP_001365214 NP_001365215 NP_001365216 NP_001365217 NP_001365218 NP_001365219 NP_001365220 NP_001106884 NP_001291383 NP_001291385 NP_036013 NP_001344009 Location (UCSC) Chr 3: 149.81 – 149.96 Mb Chr 3: 57.64 – 57.74 Mb PubMed search
Wikidata
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The protein encoded by this gene contains a RING zinc finger, a motif known to be involved in protein-protein interactions. The specific function of this gene has not yet been determined. Multiple alternatively spliced transcript variants encoding distinct isoforms have been reported.

Further reading

• Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
• Wesselkamper SC, McDowell SA, Medvedovic M, et al. (2006). "The role of metallothionein in the pathogenesis of acute lung injury". Am. J. Respir. Cell Mol. Biol. 34 (1): 73–82. doi:10.1165/rcmb.2005-0248OC. PMC 2644192. PMID 16166738.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Yu W, Andersson B, Worley KC, et al. (1997). "Large-scale concatenation cDNA sequencing". Genome Res. 7 (4): 353–8. doi:10.1101/gr.7.4.353. PMC 139146. PMID 9110174.
• Andersson B, Wentland MA, Ricafrente JY, et al. (1996). "A "double adaptor" method for improved shotgun library construction". Anal. Biochem. 236 (1): 107–13. doi:10.1006/abio.1996.0138. PMID 8619474.
• Tranque P, Crossin KL, Cirelli C, et al. (1996). "Identification and characterization of a RING zinc finger gene (C-RZF) expressed in chicken embryo cells". Proc. Natl. Acad. Sci. U.S.A. 93 (7): 3105–9. Bibcode:1996PNAS...93.3105T. doi:10.1073/pnas.93.7.3105. PMC 39769. PMID 8610176.