RCBTB1

RCBTB1
Identifiers
Aliases	RCBTB1, CLLD7, CLLL7, GLP, RCC1 and BTB domain containing protein 1, RDEOA
External IDs	OMIM: 607867; MGI: 1918580; HomoloGene: 10061; GeneCards: RCBTB1; OMA:RCBTB1 - orthologs
Gene location (Mouse)
Chr.	Chromosome 14 (mouse)
End	59,474,714 bp
RNA expression pattern
	n/a
	Top expressed in
	gastrula; ; deep cerebellar nuclei; ; tail of embryo; ; ventricular zone; ; submandibular gland; ; ganglionic eminence; ; genital tubercle; ; globus pallidus; ; ventral tegmental area; ; pineal gland;
	More reference expression data
Orthologs
	55213
	71330
	ENSG00000136144
	ENSMUSG00000035469
	Q8NDN9
	Q6NXM2
	NM_018191
	NM_027764; NM_001360610; NM_001360611
NP_060661; NP_001339429; NP_001339430; NP_001339431; NP_001339432;
	NP_001339433; NP_001339434; NP_001339435
	NP_082040; NP_001347539; NP_001347540
	Wikidata
View/Edit Human	View/Edit Mouse

RCC1 and BTB domain-containing protein 1 is a protein that in humans is encoded by the RCBTB1 gene.^[4]^[5]

This gene encodes a protein with an N-terminal RCC1 domain and a C-terminal BTB (broad complex, tramtrack and bric-a-brac) domain. In rats, over-expression of this gene in vascular smooth muscle cells induced cellular hypertrophy. The C-terminus of RCBTB1 interacts with the angiotensin II receptor-1A. In humans, this gene maps to a region of chromosome 13q that is frequently deleted in B-cell chronic lymphocytic leukemia and other lymphoid malignancies.^[5]

References

^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000035469 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Mabuchi H, Fujii H, Calin G, Alder H, Negrini M, Rassenti L, Kipps TJ, Bullrich F, Croce CM (Apr 2001). "Cloning and characterization of CLLD6, CLLD7, and CLLD8, novel candidate genes for leukemogenesis at chromosome 13q14, a region commonly deleted in B-cell chronic lymphocytic leukemia". Cancer Res. 61 (7): 2870–7. PMID 11306461.
^ ^a ^b "Entrez Gene: RCBTB1 regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 1".

Hartley JL, Temple GF, Brasch MA (2001). "DNA Cloning Using In Vitro Site-Specific Recombination". Genome Res. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC 310948. PMID 11076863.
Wiemann S, Weil B, Wellenreuther R, et al. (2001). "Toward a Catalog of Human Genes and Proteins: Sequencing and Analysis of 500 Novel Complete Protein Coding Human cDNAs". Genome Res. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166.
Simpson JC, Wellenreuther R, Poustka A, et al. (2001). "Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing". EMBO Rep. 1 (3): 287–92. doi:10.1093/embo-reports/kvd058. PMC 1083732. PMID 11256614.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Solomou EE, Sfikakis PP, Kotsi P, et al. (2004). "13q deletion in chronic lymphocytic leukemia: characterization of E4.5, a novel chromosome condensation regulator-like guanine nucleotide exchange factor". Leuk. Lymphoma. 44 (9): 1579–85. doi:10.3109/10428190309178782. PMID 14565662. S2CID 41439989.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Guo DF, Tardif V, Ghelima K, et al. (2004). "A novel angiotensin II type 1 receptor-associated protein induces cellular hypertrophy in rat vascular smooth muscle and renal proximal tubular cells". J. Biol. Chem. 279 (20): 21109–20. doi:10.1074/jbc.M401544200. PMID 14985364.
Dunham A, Matthews LH, Burton J, et al. (2004). "The DNA sequence and analysis of human chromosome 13". Nature. 428 (6982): 522–8. Bibcode:2004Natur.428..522D. doi:10.1038/nature02379. PMC 2665288. PMID 15057823.
Wiemann S, Arlt D, Huber W, et al. (2004). "From ORFeome to Biology: A Functional Genomics Pipeline". Genome Res. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMC 528930. PMID 15489336.
Mehrle A, Rosenfelder H, Schupp I, et al. (2006). "The LIFEdb database in 2006". Nucleic Acids Res. 34 (Database issue): D415–8. doi:10.1093/nar/gkj139. PMC 1347501. PMID 16381901.

This article on a gene on human chromosome 13 is a stub. You can help Wikipedia by expanding it.

[refGRCm38Ensembl-1] GRCm38: Ensembl release 89: ENSMUSG00000035469 – Ensembl, May 2017

[2] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[3] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid11306461-4] Mabuchi H, Fujii H, Calin G, Alder H, Negrini M, Rassenti L, Kipps TJ, Bullrich F, Croce CM (Apr 2001). "Cloning and characterization of CLLD6, CLLD7, and CLLD8, novel candidate genes for leukemogenesis at chromosome 13q14, a region commonly deleted in B-cell chronic lymphocytic leukemia". Cancer Res. 61 (7): 2870–7. PMID 11306461.

[entrez-5] "Entrez Gene: RCBTB1 regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 1".

[4]

[5]

[1]

[2]

[3]

RCBTB1

References

Further reading