Recombination signal binding protein for immunoglobulin kappa J region is a protein that in humans is encoded by the RBPJ gene.[5][6][7]

RBPJ
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesRBPJ, AOS3, CBF1, IGKJRB, IGKJRB1, KBF2, RBP-J, RBPJK, RBPSUH, SUH, csl, recombination signal binding protein for immunoglobulin kappa J region, RBP-J kappa, RBP-JK, CBF-1
External IDsOMIM: 147183; MGI: 96522; HomoloGene: 7511; GeneCards: RBPJ; OMA:RBPJ - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001080927
NM_001080928
NM_001277116
NM_009035
NM_001359152

RefSeq (protein)

NP_001074396
NP_001074397
NP_001264045
NP_033061
NP_001346081

Location (UCSC)Chr 4: 26.16 – 26.44 MbChr 5: 53.62 – 53.81 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

RBPJ[8] also known as CBF1, is the human homolog for the Drosophila gene Suppressor of Hairless. Its promoter region is classically used to demonstrate Notch1 signaling.[9]

Interactions

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RBPJ has been shown to interact with:

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000168214Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000039191Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Amakawa R, Jing W, Ozawa K, et al. (August 1993). "Human Jk recombination signal binding protein gene (IGKJRB): comparison with its mouse homologue". Genomics. 17 (2): 306–315. doi:10.1006/geno.1993.1326. PMID 8406481.
  6. ^ Tang X, Saito-Ohara F, Song J, et al. (June 1997). "Assignment of the human gene for KBF2/RBP-Jk to chromosome 9p12-13 and 9q13 by fluorescence in situ hybridization". The Japanese Journal of Human Genetics. 42 (2): 337–341. doi:10.1007/BF02766956. PMID 9290259.
  7. ^ "NCBI Gene: RBPJ recombination signal binding protein for immunoglobulin kappa J region".
  8. ^ "HGNC: RBPJ Symbol Report".
  9. ^ Hsieh JJ, Henkel T, Salmon P, et al. (March 1996). "Truncated mammalian Notch1 activates CBF1/RBPJk-repressed genes by a mechanism resembling that of Epstein-Barr virus EBNA2". Molecular and Cellular Biology. 16 (3): 952–959. doi:10.1128/mcb.16.3.952. PMC 231077. PMID 8622698.
  10. ^ Nam Y, Weng AP, Aster JC, et al. (June 2003). "Structural requirements for assembly of the CSL.intracellular Notch1.Mastermind-like 1 transcriptional activation complex". The Journal of Biological Chemistry. 278 (23): 21232–21239. doi:10.1074/jbc.M301567200. PMID 12644465.
  11. ^ Aster JC, Robertson ES, Hasserjian RP, et al. (April 1997). "Oncogenic forms of NOTCH1 lacking either the primary binding site for RBP-Jkappa or nuclear localization sequences retain the ability to associate with RBP-Jkappa and activate transcription". The Journal of Biological Chemistry. 272 (17): 11336–11343. doi:10.1074/jbc.272.17.11336. PMID 9111040.
  12. ^ Beatus P, Lundkvist J, Oberg C, et al. (June 2001). "The origin of the ankyrin repeat region in Notch intracellular domains is critical for regulation of HES promoter activity". Mechanisms of Development. 104 (1–2): 3–20. doi:10.1016/s0925-4773(01)00373-2. PMID 11404076. S2CID 9526831.
  13. ^ Zhou S, Hayward SD (September 2001). "Nuclear localization of CBF1 is regulated by interactions with the SMRT corepressor complex". Molecular and Cellular Biology. 21 (18): 6222–6232. doi:10.1128/mcb.21.18.6222-6232.2001. PMC 87339. PMID 11509665.
  14. ^ Kurooka H, Honjo T (June 2000). "Functional interaction between the mouse notch1 intracellular region and histone acetyltransferases PCAF and GCN5". The Journal of Biological Chemistry. 275 (22): 17211–17220. doi:10.1074/jbc.M000909200. PMID 10747963.
  15. ^ a b Zhou S, Fujimuro M, Hsieh JJ, et al. (February 2000). "A role for SKIP in EBNA2 activation of CBF1-repressed promoters". Journal of Virology. 74 (4): 1939–1947. doi:10.1128/jvi.74.4.1939-1947.2000. PMC 111672. PMID 10644367.
  16. ^ Hsieh JJ, Zhou S, Chen L, et al. (January 1999). "CIR, a corepressor linking the DNA binding factor CBF1 to the histone deacetylase complex". Proceedings of the National Academy of Sciences of the United States of America. 96 (1): 23–28. Bibcode:1999PNAS...96...23H. doi:10.1073/pnas.96.1.23. PMC 15086. PMID 9874765.
  17. ^ Zhou S, Fujimuro M, Hsieh JJ, et al. (April 2000). "SKIP, a CBF1-associated protein, interacts with the ankyrin repeat domain of NotchIC To facilitate NotchIC function". Molecular and Cellular Biology. 20 (7): 2400–2410. doi:10.1128/mcb.20.7.2400-2410.2000. PMC 85419. PMID 10713164.
  18. ^ Overman J, Fontaine F, Wylie-Sears J, et al. (July 2019). van Lohuizen M, Koh GY, Ostergaard P (eds.). "R-propranolol is a small molecule inhibitor of the SOX18 transcription factor in a rare vascular syndrome and hemangioma". eLife. 8: e43026. doi:10.7554/eLife.43026. PMC 6667216. PMID 31358114.
  19. ^ Díaz-Trelles R, Scimia MC, Bushway P, et al. (June 2016). "Notch-independent RBPJ controls angiogenesis in the adult heart". Nature Communications. 7 (1): 12088. Bibcode:2016NatCo...712088D. doi:10.1038/ncomms12088. PMC 4931341. PMID 27357444.

Further reading

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This article incorporates text from the United States National Library of Medicine, which is in the public domain.