RBM12

RBM12
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1WEL, 2CPY, 2DNN, 2EK1, 2EK6
Identifiers
Aliases	RBM12, HRIHFB2091, SWAN, RNA binding motif protein 12, SCZD19
External IDs	OMIM: 607179; MGI: 1922960; HomoloGene: 34993; GeneCards: RBM12; OMA:RBM12 - orthologs
Gene location (Human)
Chr.	Chromosome 20 (human)
End	35,664,956 bp
Gene location (Mouse)
Chr.	Chromosome 2 (mouse)
End	155,953,898 bp
RNA expression pattern
	Top expressed in
	Achilles tendon; ; epithelium of colon; ; secondary oocyte; ; bone marrow cells; ; embryo; ; ganglionic eminence; ; islet of Langerhans; ; amniotic fluid; ; ventricular zone; ; cartilage tissue;
	Top expressed in
	primitive streak; ; tail of embryo; ; genital tubercle; ; abdominal wall; ; aortic valve; ; mandibular prominence; ; maxillary prominence; ; ureter; ; hair follicle; ; somite;
	More reference expression data
	n/a
Orthologs
	10137
	75710
	ENSG00000244462
	ENSMUSG00000089824
	Q9NTZ6
	Q8R4X3
	NM_152838; NM_001198838; NM_001198840; NM_006047
	NM_029397; NM_170598
	NP_001185767; NP_001185769; NP_006038; NP_690051
	NP_083673; NP_733486
	Wikidata
View/Edit Human	View/Edit Mouse

RNA-binding protein 12 is a protein that in humans is encoded by the RBM12 gene.^[5]^[6]

This gene encodes a protein that contains several RNA-binding motifs, potential transmembrane domains, and proline-rich regions. This gene and the gene for copine I overlap at map location 20q11.21. Alternative splicing in the 5' UTR results in two transcript variants. Both variants encode the same protein.^[6]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000244462 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000089824 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Stover C, Gradl G, Jentsch I, Speicher MR, Wieser R, Schwaeble W (Jul 2001). "cDNA cloning, chromosome assignment, and genomic structure of a human gene encoding a novel member of the RBM family". Cytogenet Cell Genet. 92 (3–4): 225–30. doi:10.1159/000056908. PMID 11435693. S2CID 20555964.
^ ^a ^b "Entrez Gene: RBM12 RNA binding motif protein 12".

Nakajima D, Okazaki N, Yamakawa H, et al. (2003). "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones". DNA Res. 9 (3): 99–106. doi:10.1093/dnares/9.3.99. PMID 12168954.
Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983. S2CID 7827573.
Kofler M, Motzny K, Freund C (2006). "GYF domain proteomics reveals interaction sites in known and novel target proteins". Mol. Cell. Proteomics. 4 (11): 1797–811. doi:10.1074/mcp.M500129-MCP200. PMID 16120600.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Brill LM, Salomon AR, Ficarro SB, et al. (2004). "Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry". Anal. Chem. 76 (10): 2763–72. doi:10.1021/ac035352d. PMID 15144186.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Nakayama M, Kikuno R, Ohara O (2003). "Protein-protein interactions between large proteins: two-hybrid screening using a functionally classified library composed of long cDNAs". Genome Res. 12 (11): 1773–84. doi:10.1101/gr.406902. PMC 187542. PMID 12421765.
Deloukas P, Matthews LH, Ashurst J, et al. (2002). "The DNA sequence and comparative analysis of human chromosome 20". Nature. 414 (6866): 865–71. Bibcode:2001Natur.414..865D. doi:10.1038/414865a. PMID 11780052.
Nagase T, Ishikawa K, Suyama M, et al. (1999). "Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 5 (5): 277–86. doi:10.1093/dnares/5.5.277. PMID 9872452.
Ueki N, Oda T, Kondo M, et al. (1999). "Selection system for genes encoding nuclear-targeted proteins". Nat. Biotechnol. 16 (13): 1338–42. doi:10.1038/4315. PMID 9853615. S2CID 20001769.

External links

RBM12 human gene location in the UCSC Genome Browser.
RBM12 human gene details in the UCSC Genome Browser.

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[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000244462 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000089824 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid11435693-5] Stover C, Gradl G, Jentsch I, Speicher MR, Wieser R, Schwaeble W (Jul 2001). "cDNA cloning, chromosome assignment, and genomic structure of a human gene encoding a novel member of the RBM family". Cytogenet Cell Genet. 92 (3–4): 225–30. doi:10.1159/000056908. PMID 11435693. S2CID 20555964.

[entrez-6] "Entrez Gene: RBM12 RNA binding motif protein 12".

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[6]

[1]

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[4]

RBM12

References

Further reading

External links