Retinoic acid receptor responder protein 3 is a protein that in humans is encoded by the RARRES3 gene.[3][4]

PLAAT4
Available structures
PDBHuman UniProt search: PDBe RCSB
Identifiers
AliasesPLAAT4, HRASLS4, HRSL4, PLA1/2-3, RIG1, TIG3, retinoic acid receptor responder 3, PLAAT-4, RARRES3, phospholipase A and acyltransferase 4
External IDsOMIM: 605092; HomoloGene: 48290; GeneCards: PLAAT4; OMA:PLAAT4 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_004585

n/a

RefSeq (protein)

NP_004576

n/a

Location (UCSC)Chr 11: 63.54 – 63.55 Mbn/a
PubMed search[2]n/a
Wikidata
View/Edit Human

Retinoids exert biologic effects such as potent growth inhibitory and cell differentiation activities and are used in the treatment of hyperproliferative dermatological diseases. These effects are mediated by specific nuclear receptor proteins that are members of the steroid and thyroid hormone receptor superfamily of transcriptional regulators. RARRES1, RARRES2, and RARRES3 are genes whose expression is upregulated by the synthetic retinoid tazarotene. RARRES3 is thought act as a tumor suppressor or growth regulator.[4]

Interactions

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RARRES3 has been shown to interact with RNF135.[5]

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000133321Ensembl, May 2017
  2. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  3. ^ Duvic M, Nagpal S, Asano AT, Chandraratna RA (Sep 1997). "Molecular mechanisms of tazarotene action in psoriasis". J Am Acad Dermatol. 37 (2 Pt 3): S18–24. doi:10.1016/s0190-9622(97)80396-9. PMID 9270552.
  4. ^ a b "Entrez Gene: RARRES3 retinoic acid receptor responder (tazarotene induced) 3".
  5. ^ Oshiumi, Hiroyuki; Matsumoto Misako; Hatakeyama Shigetsugu; Seya Tsukasa (Jan 2009). "Riplet/RNF135, a RING finger protein, ubiquitinates RIG-I to promote interferon-beta induction during the early phase of viral infection". J. Biol. Chem. 284 (2). United States: 807–17. doi:10.1074/jbc.M804259200. ISSN 0021-9258. PMID 19017631.

Further reading

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