RAP1GAP2

RAP1 GTPase activating protein 2 is a protein in humans that is encoded by the RAP1GAP2 gene.

RAP1GAP2
Identifiers
Aliases	RAP1GAP2, GARNL4, RAP1GA3, RAP1 GTPase activating protein 2
External IDs	MGI: 3028623; HomoloGene: 56695; GeneCards: RAP1GAP2; OMA:RAP1GAP2 - orthologs
Gene location (Human) Chr. Chromosome 17 (human) Band 17p13.3 Start 2,755,705 bp End 3,037,741 bp
Gene location (Mouse) Chr. Chromosome 11 (mouse) Band 11|11 B5 Start 74,274,182 bp End 74,501,741 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in Brodmann area 23 middle temporal gyrus endothelial cell superior frontal gyrus right hemisphere of cerebellum islet of Langerhans postcentral gyrus cerebellar vermis entorhinal cortex beta cell Top expressed in islet of Langerhans primary motor cortex medial vestibular nucleus submandibular gland prefrontal cortex deep cerebellar nuclei cingulate gyrus pontine nuclei dentate gyrus of hippocampal formation granule cell epithelium of stomach More reference expression data BioGPS n/a
Gene ontology Molecular function protein binding GTPase activator activity Cellular component perinuclear region of cytoplasm neuron projection centrosome plasma membrane nuclear membrane cytoplasm cytosol Biological process regulation of cell size positive regulation of GTPase activity negative regulation of neuron projection development regulation of small GTPase mediated signal transduction Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 23108 380711 Ensembl ENSG00000132359 ENSMUSG00000038807 UniProt Q684P5 Q5SVL6 RefSeq (mRNA) NM_001100398 NM_015085 NM_001330058 NM_001015046 NM_001364131 NM_001364132 RefSeq (protein) NP_001093868 NP_001316987 NP_055900 NP_001015046 NP_001351060 NP_001351061 NP_001388587 Location (UCSC) Chr 17: 2.76 – 3.04 Mb Chr 11: 74.27 – 74.5 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

This gene encodes a GTPase-activating protein that activates the small guanine-nucleotide-binding protein Rap1 in platelets. The protein interacts with synaptotagmin-like protein 1 and Rab27 and regulates secretion of dense granules from platelets at sites of endothelial damage. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009].

Further reading

• Neumüller O, Hoffmeister M, Babica J, Prelle C, Gegenbauer K, Smolenski AP (August 2009). "Synaptotagmin-like protein 1 interacts with the GTPase-activating protein Rap1GAP2 and regulates dense granule secretion in platelets". Blood. 114 (7): 1396–404. doi:10.1182/blood-2008-05-155234. hdl:10197/5848. PMID 19528539. S2CID 24339637.
• Aouizerat BE, Vittinghoff E, Musone SL, Pawlikowska L, Kwok PY, Olgin JE, Tseng ZH (June 2011). "GWAS for discovery and replication of genetic loci associated with sudden cardiac arrest in patients with coronary artery disease". BMC Cardiovascular Disorders. 11: 29. doi:10.1186/1471-2261-11-29. PMC 3141757. PMID 21658281.
• Balduini A, Pecci A, Lova P, Arezzi N, Marseglia C, Bellora F, Perotti C, Balduini C, Balduini CL, Torti M (October 2004). "Expression, activation, and subcellular localization of the Rap1 GTPase in cord blood-derived human megakaryocytes". Experimental Cell Research. 300 (1): 84–93. doi:10.1016/j.yexcr.2004.07.011. PMID 15383317.
• Kimura T, Mogi C, Sato K, Tomura H, Ohta H, Im DS, Kuwabara A, Kurose H, Murakami M, Okajima F (October 2011). "p2y5/LPA(6) attenuates LPA(1)-mediated VE-cadherin translocation and cell-cell dissociation through G(12/13) protein-Src-Rap1". Cardiovascular Research. 92 (1): 149–58. doi:10.1093/cvr/cvr154. PMID 21632882.
• Schultess J, Danielewski O, Smolenski AP (April 2005). "Rap1GAP2 is a new GTPase-activating protein of Rap1 expressed in human platelets". Blood. 105 (8): 3185–92. doi:10.1182/blood-2004-09-3605. hdl:10197/5867. PMID 15632203.
• Hoffmeister M, Riha P, Neumüller O, Danielewski O, Schultess J, Smolenski AP (January 2008). "Cyclic nucleotide-dependent protein kinases inhibit binding of 14-3-3 to the GTPase-activating protein Rap1GAP2 in platelets" (PDF). The Journal of Biological Chemistry. 283 (4): 2297–306. doi:10.1074/jbc.M706825200. PMID 18039662. S2CID 20190382.