RAB11FIP3

Rab11 family-interacting protein 3 is a protein that in humans is encoded by the RAB11FIP3 gene.

RAB11FIP3
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2D7C, 2HV8, 4D0M, 4UJ3, 4UJ4
Identifiers
Aliases	RAB11FIP3, CART1, Rab11-FIP3, RAB11 family interacting protein 3, FIP3-Rab11
External IDs	OMIM: 608738; MGI: 2444431; HomoloGene: 49396; GeneCards: RAB11FIP3; OMA:RAB11FIP3 - orthologs
Gene location (Human) Chr. Chromosome 16 (human) Band 16p13.3 Start 425,649 bp End 523,011 bp
Gene location (Mouse) Chr. Chromosome 17 (mouse) Band 17|17 A3.3 Start 26,208,010 bp End 26,288,529 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in pancreatic ductal cell right hemisphere of cerebellum human kidney sural nerve renal medulla renal cortex visceral pleura right frontal lobe cingulate gyrus anterior cingulate cortex Top expressed in right kidney proximal tubule human kidney knee joint muscle of thigh dentate gyrus of hippocampal formation granule cell primary visual cortex superior frontal gyrus skeletal muscle tissue neural layer of retina More reference expression data BioGPS More reference expression data
Gene ontology Molecular function calcium ion binding protein homodimerization activity metal ion binding protein binding dynein light intermediate chain binding Cellular component cytoplasm recycling endosome cytosol endosome centrosome intracellular membrane-bounded organelle membrane nucleoplasm microtubule organizing center recycling endosome membrane midbody intercellular bridge cleavage furrow cytoskeleton endocytic vesicle Biological process cell division endocytic recycling cell cycle negative regulation of adiponectin secretion vesicle-mediated transport cytokinesis regulation of cytokinesis protein localization to cilium Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 9727 215445 Ensembl ENSG00000090565 ENSG00000275338 ENSMUSG00000037098 UniProt O75154 Q8CHD8 RefSeq (mRNA) NM_001142272 NM_014700 NM_001370401 NM_001162868 NM_001162869 NM_153140 RefSeq (protein) NP_001135744 NP_055515 NP_001357330 NP_001156340 NP_001156341 NP_694780 Location (UCSC) Chr 16: 0.43 – 0.52 Mb Chr 17: 26.21 – 26.29 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

Proteins of the large Rab GTPase family (see RAB1A; MIM 179508) have regulatory roles in the formation, targeting, and fusion of intracellular transport vesicles. RAB11FIP3 is one of many proteins that interact with and regulate Rab GTPases (Hales et al., 2001).[supplied by OMIM]

Interactions

RAB11FIP3 has been shown to interact with RAB11A.

Further reading

• Shin OH, Ross AH, Mihai I, Exton JH (2000). "Identification of arfophilin, a target protein for GTP-bound class II ADP-ribosylation factors". J. Biol. Chem. 274 (51): 36609–15. doi:10.1074/jbc.274.51.36609. PMID 10593962.
• Daniels RJ, Peden JF, Lloyd C, et al. (2001). "Sequence, structure and pathology of the fully annotated terminal 2 Mb of the short arm of human chromosome 16". Hum. Mol. Genet. 10 (4): 339–52. doi:10.1093/hmg/10.4.339. PMID 11157797.
• Hales CM, Griner R, Hobdy-Henderson KC, et al. (2001). "Identification and characterization of a family of Rab11-interacting proteins". J. Biol. Chem. 276 (42): 39067–75. doi:10.1074/jbc.M104831200. PMID 11495908.
• Shin OH, Couvillon AD, Exton JH (2001). "Arfophilin is a common target of both class II and class III ADP-ribosylation factors". Biochemistry. 40 (36): 10846–52. doi:10.1021/bi0107391. PMID 11535061.
• Yang CS, Weiner H (2002). "Yeast two-hybrid screening identifies binding partners of human Tom34 that have ATPase activity and form a complex with Tom34 in the cytosol". Arch. Biochem. Biophys. 400 (1): 105–10. doi:10.1006/abbi.2002.2778. PMID 11913976.
• Wallace DM, Lindsay AJ, Hendrick AG, McCaffrey MW (2003). "Rab11-FIP4 interacts with Rab11 in a GTP-dependent manner and its overexpression condenses the Rab11 positive compartment in HeLa cells". Biochem. Biophys. Res. Commun. 299 (5): 770–9. doi:10.1016/S0006-291X(02)02720-1. PMID 12470645.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Behrends U, Schneider I, Rössler S, et al. (2003). "Novel tumor antigens identified by autologous antibody screening of childhood medulloblastoma cDNA libraries". Int. J. Cancer. 106 (2): 244–51. doi:10.1002/ijc.11208. PMID 12800201. S2CID 36836051.
• Horgan CP, Walsh M, Zurawski TH, McCaffrey MW (2004). "Rab11-FIP3 localises to a Rab11-positive pericentrosomal compartment during interphase and to the cleavage furrow during cytokinesis". Biochem. Biophys. Res. Commun. 319 (1): 83–94. doi:10.1016/j.bbrc.2004.04.157. PMID 15158446.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Wilson GM, Fielding AB, Simon GC, et al. (2005). "The FIP3-Rab11 protein complex regulates recycling endosome targeting to the cleavage furrow during late cytokinesis". Mol. Biol. Cell. 16 (2): 849–60. doi:10.1091/mbc.E04-10-0927. PMC 545916. PMID 15601896.
• Martin J, Han C, Gordon LA, et al. (2005). "The sequence and analysis of duplication-rich human chromosome 16". Nature. 432 (7020): 988–94. Bibcode:2004Natur.432..988M. doi:10.1038/nature03187. PMID 15616553.
• Shiba T, Koga H, Shin HW, et al. (2007). "Structural basis for Rab11-dependent membrane recruitment of a family of Rab11-interacting protein 3 (FIP3)/Arfophilin-1". Proc. Natl. Acad. Sci. U.S.A. 103 (42): 15416–21. Bibcode:2006PNAS..10315416S. doi:10.1073/pnas.0605357103. PMC 1622838. PMID 17030804.
• Horgan CP, Oleksy A, Zhdanov AV, et al. (2007). "Rab11-FIP3 is critical for the structural integrity of the endosomal recycling compartment" (PDF). Traffic. 8 (4): 414–30. doi:10.1111/j.1600-0854.2007.00543.x. PMID 17394487.
• Schonteich E, Pilli M, Simon GC, et al. (2007). "Molecular characterization of Rab11-FIP3 binding to ARF GTPases". Eur. J. Cell Biol. 86 (8): 417–31. doi:10.1016/j.ejcb.2007.05.004. PMID 17628206.