In Greek mythology, Pyrene (Ancient Greek: Πυρήνη) may refer to:
- Pyrene, daughter of King Bebrycius and a lover (or victim, depending on the myth) of Heracles. She bore a serpent and became so terrified that she fled to the woods where she died. Heracles created a tomb for her by piling up rocks thus forming the mountain range of the Pyrenees, named after her.
- Pyrene, also called Pelopia, mother of Cycnus with Ares.
- ^ Silius Italicus, Punica, 3. 415-446
- ^ Bell's New Pantheon Or Historical Dictionary of the Gods, Demi Gods, page 203 
- ^ (Anonymous) A classical manual, being a mythological, historical, and geographical commentary on Pope's Homer and Dryden's Aeneid of Virgil. London, J. Murray, 1833. p. 
- ^ Pseudo-Apollodorus, Bibliotheca 2.5.1