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The Pseudomon-groES RNA motif is a conserved RNA structure identified in certain bacteria using bioinformatics.[1] It is found in most species within the family Pseudomonadaceae, and is consistently located in the 5' untranslated regions (5' UTRs) of operons that contain groES genes. RNA transcripts of the groES genes in Pseudomonas aeruginosa where shown experimentally to be initiated at one of two start sites, from promoters called "P1" and "P2" [2] (see diagram). The Pseudomon-groES RNA is in the 5' UTR of transcripts initiated from the P1 site, but is truncated in P2 transcripts. groES genes are involved in the cellular response to heat shock, but it is not thought that the Pseudomonas-groES RNA motif is involved in heat shock regulation. However, it is thought that the motif might regulate groES genes in response to other stimuli.
| Pseudomon-groES | |
|---|---|
 Consensus secondary structure of Pseudomon-groES RNAs | |
| Identifiers | |
| Symbol | Pseudomonas-groES |
| Rfam | RF01721 |
| Other data | |
| RNA type | Cis-regulatory element |
| PDB structures | PDBe |
References edit
- ^ Weinberg Z, Wang JX, Bogue J, et al. (March 2010). "Comparative genomics reveals 104 candidate structured RNAs from bacteria, archaea and their metagenomes". Genome Biol. 11 (3): R31. doi:10.1186/gb-2010-11-3-r31. PMC 2864571. PMID 20230605.
- ^ Fujita M, Amemura A, Aramaki H (June 1998). "Transcription of the groESL operon in Pseudomonas aeruginosa PAO1". FEMS Microbiol. Lett. 163 (2): 237–242. doi:10.1111/j.1574-6968.1998.tb13051.x. PMID 9673028.
External links edit
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