Portuondo is a surname of Spanish origin. Notable people with the surname include:
- Bartolo Portuondo (1893–1981), Cuban baseball player
- Emilio Núñez Portuondo (1898–1978), Cuban politician, lawyer and diplomat
- Omara Portuondo (born 1930), Cuban singer and dancer
- Diego Portuondo (1981-), Spanish photographer, gallerist, interior designer
- Yasser Portuondo (born 1983), Cuban volleyball player