Portsmouth High School may refer to:
- United Kingdom
- Portsmouth High School (Southsea) — Southsea, England
- United States
- Portsmouth Abbey School — Portsmouth, Rhode Island (private school)
- Portsmouth High School (Rhode Island) — Portsmouth, Rhode Island (public school)
- Portsmouth High School (New Hampshire) — Portsmouth, New Hampshire
- Portsmouth High School (Ohio) — Portsmouth, Ohio
- Portsmouth West High School — West Portsmouth, Ohio
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