- September 12, 1970 - Luna 16 launched on 1st unmanned lunar sample return mission.
- September 14, 1959 - Luna 2 makes the 1st lunar impact.
- September 16, 1994 - Carl J. Meade makes a 3½ hour untethered spacewalk to test the Simplified Aid For EVA Rescue.
- September 18, 1980 - Arnaldo Tamayo-Mendez becomes the first Cuban and the first black person to fly in space on Soyuz 38.
- September 26, 1983 - Soyuz T-10-1 explodes on the launchpad two seconds after the crew is saved by the escape system. They land 4 kilometers away.
- September 28, 1988 - STS-26 sees the Space Shuttle Discovery launch on NASA's return to flight after the Challenger Disaster
- September 29, 2004 - Mike Melvill makes the first of two flights (second flight overall) in SpaceShipOne to capture the Ansari X Prize
