Francis Borgia, the son of Juan Borgia, the 3rd Duke of Gandia and Joana of Aragon, daughter of Afonso de Aragon, Archbishop of Zaragoza, who, in turn, was the illegitimate son of Ferdinand the Catholic (Ferdinand II of Aragon) and his mistress Aldonza Ruiz de Iborre y Alemany. Francis was also the paternal great-grandson of Pope Alexander VI.