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Plague vaccine is a vaccine used against Yersinia pestis.[1] Killed bacteria have been used since 1890 but are less effective against pneumonic plague so that recently live vaccines of an attenuated type and recombination protein vaccines have been developed to prevent the disease.[2]

Plague vaccine
Man being injected by doctor, during the outbreak of bubonic Wellcome V0029287.jpg
Plague vaccine being administered
Vaccine description
Target diseaseYersinia pestis
TypeLive bacteria
Clinical data
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ATC code
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Plague immunizationEdit

A plague vaccine is used for an induction of active specific immunity in a susceptible organism to plague by means of administration an antigenic material (a vaccine) via a variety of routes to people at risk of contracting any clinical form of plague. This method is known as plague immunization. There is strong evidence for the efficacy of administration of some plague vaccines in preventing or ameliorating the effects of a variety of clinical forms of infection by Yersinia pestis. Plague immunization also encompasses incurring state of passive specific immunity to plague in a susceptible organism after administration of a plague serum or plague immunological in people with an immediate risk of developing the disease.[3]

Many areas that are affected by plague in modern times are third world countries, and therefore cannot get accurate diagnosis or decent medical care for any sufferers of bubonic or pneumonic plague.

A systematic review by the Cochrane Collaboration found no studies of sufficient quality to be included in the review, and were thus unable to make any statement on the efficacy of the vaccine.[4]


  1. ^ Plague+Vaccine at the US National Library of Medicine Medical Subject Headings (MeSH)
  2. ^ Bubeck SS, Dube PH (September 2006). "Yersinia pestis CO92ΔyopH Is a Potent Live, Attenuated Plague Vaccine". Clin. Vaccine Immunol. 14 (9): 1235–8. doi:10.1128/CVI.00137-07. PMC 2043315. PMID 17652523.
  3. ^
  4. ^ Jefferson T, Demicheli V, Pratt M (2000). "Vaccines for preventing plague". Cochrane Database Syst Rev (2): CD000976. doi:10.1002/14651858.CD000976. PMID 10796565.