In bacteria, PinT small RNA is a small regulatory RNA (sRNA) that is activated during stress and virulence conditions. sRNAs base-pair with target mRNAs and modulate their stability or translation. The expression of PhoP-activated sRNA called PinT is highly induced during Salmonella enterica infection. PinT temporally controls Salmonella virulence genes. On bacterial internalization it controls the expression of invasion associated effectors (SPI-1) through the direct base-pairing with the mRNA. Later in infection it represses the virulence genes (SPI-2) allowing the switch from an invasive state to the state of intracellular replication.[1]
| PinT sRNA | |
|---|---|
 Predicted secondary structure and sequence conservation of PinT small RNA | |
| Identifiers | |
| Rfam | RF01404 |
| Other data | |
| Domain(s) | Bacteria |
| SO | SO:0001263 |
| PDB structures | PDBe |
References edit
- ^ Westermann AJ, Förstner KU, Amman F, Barquist L, Chao Y, Schulte LN, Müller L, Reinhardt R, Stadler PF, Vogel J (January 2016). "Dual RNA-seq unveils noncoding RNA functions in host-pathogen interactions". Nature. 529 (7587): 496–501. doi:10.1038/nature16547. PMID 26789254.