Piersanti is both an Italian surname and a masculine Italian given name. Notable people with the name include:
Surname:
- Cactus Pete Piersanti (1916–1994), American businessman
- Franco Piersanti (born 1950), Italian composer and conductor
- Umberto Piersanti (born 1941), Italian poet and writer
Given name:
- Piersanti Mattarella (1935–1980), Italian politician