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Phenindione is an anticoagulant which functions as a Vitamin K antagonist.

Phenindione
Phenindione.svg
Clinical data
AHFS/Drugs.comInternational Drug Names
Pregnancy
category
  • AU: D
Routes of
administration
Oral
ATC code
Pharmacokinetic data
Protein binding88%
Elimination half-life5 to 10 hours
Identifiers
CAS Number
PubChem CID
IUPHAR/BPS
DrugBank
ChemSpider
UNII
KEGG
ChEBI
ChEMBL
ECHA InfoCard100.001.323 Edit this at Wikidata
Chemical and physical data
FormulaC15H10O2
Molar mass222.239 g/mol
3D model (JSmol)
  (verify)

Phenindione was introduced in the early 1950s. It acts similar to warfarin, but it has been associated with hypersensitivity reactions, so it is rarely used and warfarin is preferred.[1][2]

ReferencesEdit

  1. ^ Naisbitt DJ, Farrell J, Chamberlain PJ, et al. (June 2005). "Characterization of the T-cell response in a patient with phenindione hypersensitivity". J. Pharmacol. Exp. Ther. 313 (3): 1058–65. doi:10.1124/jpet.105.083758. PMID 15743920.
  2. ^ Sean C Sweetman (Ed) (2009). Martindale: The Complete Drug Reference (36th ed.). London: Phamaceutical Press. "Phenindione", p. 1369.

External linksEdit