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Phenindione is an anticoagulant which functions as a Vitamin K antagonist.

Phenindione
Phenindione.svg
Clinical data
AHFS/Drugs.com International Drug Names
Pregnancy
category
  • AU: D
Routes of
administration
Oral
ATC code
Pharmacokinetic data
Protein binding 88%
Biological half-life 5 to 10 hours
Identifiers
CAS Number
PubChem CID
IUPHAR/BPS
DrugBank
ChemSpider
UNII
KEGG
ChEBI
ChEMBL
ECHA InfoCard 100.001.323
Chemical and physical data
Formula C15H10O2
Molar mass 222.239 g/mol
3D model (JSmol)
  (verify)

Phenindione was introduced in the early 1950s. It acts similar to warfarin, but it has been associated with hypersensitivity reactions, so it is rarely used and warfarin is preferred.[1][2]

ReferencesEdit

  1. ^ Naisbitt DJ, Farrell J, Chamberlain PJ, et al. (June 2005). "Characterization of the T-cell response in a patient with phenindione hypersensitivity". J. Pharmacol. Exp. Ther. 313 (3): 1058–65. doi:10.1124/jpet.105.083758. PMID 15743920. 
  2. ^ Sean C Sweetman (Ed) (2009). Martindale: The Complete Drug Reference (36th ed.). London: Phamaceutical Press. "Phenindione", p. 1369. 

External linksEdit