Perls is a surname. Notable people with the surname include:

  • Alexander Perls (born 1976), American musician, entrepreneur and record producer
  • Frank Perls (1910–1975), German-born American art dealer
  • Fritz Perls (1893–1970), German-born psychiatrist and psychotherapist
  • Hugo Perls (1886–1977), German art dealer, historian, philosopher
  • Klaus Perls (1912–2008), German-American art dealer
  • Laura Perls (1905–1990), German-born psychologist and psychotherapist
  • Nick Perls (1942–1987), American audio engineer
  • Tom Perls (born 1960), American gerontologist

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