Perkiomen Creek is a 37.7-mile-long (60.7 km) tributary of the Schuylkill River in Berks, Lehigh and Montgomery counties, Pennsylvania in the United States. The water course was also named Perquaminck Creek, on Thomas Holme's 1687 map.
The creek begins in Hereford Township, Berks County, initially flows eastward into Upper Milford Township, Lehigh County, and turns southward to reenter Hereford Township before entering Montgomery County. It is from the Lenape term Pakihm Unk (pronounced for Pah Keym Unk), which means "cranberry place" in English.
Perkiomen Creek joins the Schuylkill River approximately 1.7 miles (2.7 km) downstream of the community of Audubon, the location of the National Audubon Society wildlife sanctuary Mill Grove Farm, once the estate of 19th-century ornithologist John James Audubon. Its largest tributary is East Branch Perkiomen Creek.
The Perkiomen Trail was established in 2003 as a partnership with the Montgomery County Planning Commission and local governments to provide a walking, jogging, and biking path along the creek that stretches south from Green Lane Reservoir Park to near the Schuylkill River where it meets the Schuylkill River Trail.