Perfluorohexane (C6F14), or tetradecafluorohexane, is a fluorocarbon. It is a derivative of hexane in which all of the hydrogen atoms are replaced by fluorine atoms. It is used in one formulation of the electronic cooling liquid/insulator Fluorinert for low-temperature applications due to its low boiling point of 56 °C and freezing point of −90 °C. It is odorless and colorless. Unlike typical hydrocarbons, the structure features a helical carbon backbone.
|Preferred IUPAC name
3D model (JSmol)
CompTox Dashboard (EPA)
|Density||1,680 kg/m3 (Liquid)|
|Melting point||−90 °C (−130 °F; 183 K)|
|Boiling point||56 °C (133 °F; 329 K)|
|Vapor pressure||30.9kPa @ 25 °C|
|Thermal conductivity||0.057 W/m-K|
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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Because it is biologically inert and chemically stable, perfluorohexane has attracted attention in medicine. Like other fluorocarbons, perfluorohexane dissolves gases, including oxygen from the air, to a higher concentration than ordinary organic solvents. This effect is attributed to the weak intermolecular forces between perfluorohexane molecules, which allows "space" for gas molecules to partition into the liquid. Animals can be submerged in a bath of oxygenated perfluorohexane without drowning, as there is sufficient oxygen available in the solvent to allow respiration to continue. This effect has led to the experimental use of perfluorohexane in treating burn victims, as their lungs can be filled with either perfluorohexane vapor or in extreme cases liquid perfluorohexane, allowing breathing to continue without the problems normally seen with pulmonary edema that sometimes occur when the inside of the lungs have been burnt e.g. by inhalation of hot smoke. Research was particularly active on the topic of partial liquid ventilation (PLV) in the 1990s and early 2000s, however, perfluorohexane and other perfluorocarbons showed no significant improvement of patient outcomes in clinical trials. 
Perfluorohexane has extremely high global warming potential (GWP) of 9,300. This leads to a need to find low GWP alternative. Novec™ 649 was considered a good drop-in replacement in many applications due to its similar thermo-physical properties and having a global warming potential of 1. 
- John A. Gladysz and Markus Jurisch "Structural, Physical, and Chemical Properties of Fluorous Compounds" in István T. Horváth (Ed.) Topics in Current Chemistry 2011 "Fluorous Chemistry" doi:10.1007/128_2011_282
- De Abreu, MG; Quelhas, AD; Spieth, P; Brauer, G; Knels, L; Kasper, M; Pino, AV; Bleyl, JU; Hubler, M; Bozza, F; Salluh, J; Kuhlisch, E; Giannella-Neto, A; Koch, T (Feb 2006). "Comparative effects of vaporized perfluorohexane and partial liquid ventilation in oleic acid-induced lung injury". Anesthesiology. 104 (2): 278–89. doi:10.1097/00000542-200602000-00013. PMID 16436847. S2CID 30310674.
- Bleyl, JU; Ragaller, M; Tscho, U; Regner, M; Hubler, M; Kanzow, M; Vincent, O; Albrecht, M (Jun 2002). "Changes in pulmonary function and oxygenation during application of perfluorocarbon vapor in healthy and oleic acid-injured animals". Critical Care Medicine. 30 (6): 1340–7. doi:10.1097/00003246-200206000-00034. PMID 12072692. S2CID 20292926.
- Kacmarek, Robert M.; Wiedemann, Herbert P.; Lavin, Philip T.; Wedel, Mark K.; Tütüncü, Ahmet S.; Slutsky, Arthur S. (2006-04-15). "Partial Liquid Ventilation in Adult Patients with Acute Respiratory Distress Syndrome". American Journal of Respiratory and Critical Care Medicine. 173 (8): 882–889. doi:10.1164/rccm.200508-1196OC. ISSN 1073-449X. PMID 16254269.
- "3M Novec 649 as a replacement of C6F14 in liquid cooling systems" (PDF). CERN. Retrieved April 8, 2021.