Wikipedia

Paul Khavari

Paul A. Khavari is the Carl J. Herzog Professor[1] at the Stanford University School of Medicine and the Founding Co-Director of the Stanford Program in Epithelial Biology.[2] He is an elected member of the National Academy of Medicine.[3]

The Khavari Laboratory uses multiomic and computational approaches to study stem cell differentiation, cancer, and the genomics of common polygenic human diseases.

Education edit

Khavari studied biology and history at Stanford University then earned an MD at Yale School of Medicine.[4] He did research at the Brigham and Women's Hospital[4] and Harvard Medical School before undertaking Dermatology residency training at Yale.[5] He completed PhD studies in the laboratory of Gerald Crabtree at the Stanford University School of Medicine.[6]

Academic career edit

Khavari joined the Stanford faculty in 1993,[7] and began service as Chief of Dermatology at the VA Palo Alto Healthcare System.[7][8] In 1999, he co-founded the Stanford Program in Epithelial Biology with Dr. Tony Oro and has served as Co-Director since.[9] In 2010, he was appointed Chair of the Stanford University School of Medicine Department of Dermatology,[10] a leading dermatology department globally. He was one of three Stanford faculty members elected to the Institute of Medicine (now National Academy of Medicine) in 2014.[11][1]

Research in the Khavari laboratory focuses on genome regulation, signaling, noncoding RNAs,[12] and innovating new human tissue genetic models, with a special focus on the cutaneous epidermis. The lab accomplished the first genetic corrections of human skin tissue,[13] defined the minimal oncogenic gene set needed to transform normal human tissues into cancer,[14] and identified the kinetics of human malignant transformation using novel human tissue cancer models.[15] The Khavari group also identified new essential roles for a number of regulators in epidermal homeostasis, including ZNF750, MAF, MAFB, PRMT1, CSNK1A1, EHF, MPZL3, FDXR, TINCR, and ACTL6A.[16] It uncovered new regulators and effectors of Ras GTPases, including small noncoding snoRNAs as direct Ras-binders that modulate its function and mTORC2 as a new direct Ras downstream effector critical for the pro-proliferation impacts of Ras signaling.[17] The lab defined two major classes of genomic enhancers[18] in dynamic gene regulation and used multiomics and deep learning approaches to decode the combinatorial cis-regulatory DNA motif lexicon that drives epidermal differentiation.[19] The lab has innovated a number of technologies, including single cell perturb-ATAC-seq,[20] RNA protein interaction detection (RAPID),[21] RNA-protein microarray hybridization,[22] and mosaic human skin tissue models.[23] In cancer studies, the Khavari lab identified and characterized tumor specific keratinocytes in cutaneous squamous cell cancer,[24] characterized a new tumor suppressor pathway,[25] and defined a new sunlight induced oncogene in skin cancer.[26]

Selected Honors and Awards edit

Khavari has received a number of honors and awards, including most recently the Stephan Rothman Memorial Award, the highest award given by the Society of Investigative Dermatology.[27]

2021             Stephen Rothman Memorial Award, Society for Investigative Dermatology [27]

2018             Kligman-Frost Leadership Award, Society for Investigative Dermatology

2016             Lila & Murray Gruber Cancer Research Award, American Academy of Dermatology[28]

2014             National Academy of Medicine[29]

2012             American Skin Association 25th Anniversary Lifetime Scientific Achievement Award[30]

2009             American Association of Physicians

2008             Tanioku Kihei Memorial Award, Japanese Society for Investigative Dermatology[31]

2004             Marion B. Sulzberger Memorial Award, American Academy of Dermatology[32]

2004             William Montagna Award, Society for Investigative Dermatology

1999             American Society for Clinical Investigation

1998             HHMI Junior Faculty Scholar Award, Stanford University[33]

1997             V.A. Young Investigator Award, V.A. Palo Alto Health Care System[34]

1996             U.S. Presidential Early Career Award for Scientists and Engineers

1995             Shannon Award, National Institutes of Health

Notable Trainees and their current Affiliation edit

  • Keith Choate, Yale
  • Jennifer Zhang, Duke
  • Min Fang, University of Washington
  • Yoshi Kubo, University of Tokushima
  • Cornelia Seitz, Goettingen
  • Masahito Tarutani,Tokyo University
  • Zurab Siprashvili, Stanford
  • Kun Qu, USTC
  • George Sen, UCSD
  • Susana Ortiz-Urda, UCSF
  • Todd Ridky, University of Pennsylvania
  • Kavita Sarin, Stanford
  • Jennifer Chen, Stanford
  • Lisa Boxer, NIH
  • Cari Lee, Stanford
  • Markus Kretz, University of Regensburg
  • Xiaomin Bao, Northwestern
  • Bryan Sun, UCSD
  • Eon Rios, Stanford
  • Aparna Bhaduri, UCLA
  • Andrew Ji, Mount Sinai  

References edit

  1. ^ a b "Three faculty members elected to Institute of Medicine". Stanford.edu. Retrieved 2021-05-10.
  2. ^ "Stanford University School of Medicine | SFB 829". Retrieved 2021-05-10.
  3. ^ Penn, Tiffany (October 30, 2014). "Paul Khavari, M.D. '88, Ph.D., HS '90, elected to Institute of Medicine". Yale School of Medicine. Yale.edu. Retrieved July 21, 2021.
  4. ^ a b "Med School appointments, promotions: 6/3/98". Stanford. Retrieved 2021-07-21.
  5. ^ Conger, Krista (17 January 2010). "Paul Khavari appointed dermatology chair". Stanford.edu. Retrieved 2021-07-21.
  6. ^ "Gerald Crabtree". SFARI. 2017-07-21. Retrieved 2021-05-10.
  7. ^ a b "Two young Stanford scientists receive Presidential award (1/97)". Stanford. Retrieved 2021-07-21.
  8. ^ Begley, Sharon (11 November 2005). "Nature's Many Quirks Limit the Possibilities Of DNA-Based Drugs". Wall Street Journal. ProQuest 398992336.
  9. ^ "Stanford University School of Medicine | SFB 829". Retrieved 2021-07-21.
  10. ^ Conger, Krista (17 January 2010). "Paul Khavari appointed dermatology chair". med.stanford.edu (in Samoan). Retrieved 2021-05-10.
  11. ^ "Institute of Medicine Elects 70 New Members, 10 Foreign Associates". www8.nationalacademies.org. Retrieved 2021-05-10.
  12. ^ Lee, Carolyn S.; Mah, Angela; Aros, Cody J.; Lopez-Pajares, Vanessa; Bhaduri, Aparna; Webster, Dan E.; Kretz, Markus; Khavari, Paul A. (June 2018). "Cancer-Associated Long Noncoding RNA SMRT-2 Controls Epidermal Differentiation". Journal of Investigative Dermatology. 138 (6): 1445–1449. doi:10.1016/j.jid.2018.01.003. PMC 6814294. PMID 29360484.[non-primary source needed]
  13. ^ Choate, Keith A.; Medalie, Dan A.; Morgan, Jeff R.; Khavari, Paul A. (November 1996). "Corrective gene transfer in the human skin disorder lamellar ichthyosis". Nature Medicine. 2 (11): 1263–1267. doi:10.1038/nm1196-1263. PMID 8898758. S2CID 22281798.[non-primary source needed]
  14. ^ Bolotin, Diana; Fuchs, Elaine (February 2003). "More than skin deep". Nature. 421 (6923): 594–595. doi:10.1038/421594a. PMID 12571582. S2CID 4424529.
  15. ^ Stuart, Darrin D; Sellers, William R (May 2013). "Targeting RAF-MEK-ERK kinase-scaffold interactions in cancer". Nature Medicine. 19 (5): 538–540. doi:10.1038/nm.3195. PMID 23652103. S2CID 6492513.
  16. ^ Boxer, Lisa D.; Barajas, Brook; Tao, Shiying; Zhang, Jiajing; Khavari, Paul A. (15 September 2014). "ZNF750 interacts with KLF4 and RCOR1, KDM1A, and CTBP1/2 chromatin regulators to repress epidermal progenitor genes and induce differentiation genes". Genes & Development. 28 (18): 2013–2026. doi:10.1101/gad.246579.114. PMC 4173152. PMID 25228645.[non-primary source needed]
  17. ^ Kovalski, Joanna R.; Bhaduri, Aparna; Zehnder, Ashley M.; Neela, Poornima H.; Che, Yonglu; Wozniak, Glenn G.; Khavari, Paul A. (February 2019). "The Functional Proximal Proteome of Oncogenic Ras Includes mTORC2". Molecular Cell. 73 (4): 830–844.e12. doi:10.1016/j.molcel.2018.12.001. PMC 6386588. PMID 30639242.[non-primary source needed]
  18. ^ Conger, Krista (2017-08-15). "Genome architecture guides stem cell fate, Stanford researchers find". Scope. Retrieved 2021-05-10.
  19. ^ Kim, Daniel S.; Risca, Viviana I.; Reynolds, David L.; Chappell, James; Rubin, Adam J.; Jung, Namyoung; Donohue, Laura K. H.; Lopez-Pajares, Vanessa; Kathiria, Arwa; Shi, Minyi; Zhao, Zhixin; Deep, Harsh; Sharmin, Mahfuza; Rao, Deepti; Lin, Shin; Chang, Howard Y.; Snyder, Michael P.; Greenleaf, William J.; Kundaje, Anshul; Khavari, Paul A. (November 2021). "The dynamic, combinatorial cis-regulatory lexicon of epidermal differentiation". Nature Genetics. 53 (11): 1564–1576. doi:10.1038/s41588-021-00947-3. PMC 8763320. PMID 34650237. S2CID 238990464.[non-primary source needed]
  20. ^ Rubin, Adam J.; Parker, Kevin R.; Satpathy, Ansuman T.; Qi, Yanyan; Wu, Beijing; Ong, Alvin J.; Mumbach, Maxwell R.; Ji, Andrew L.; Kim, Daniel S.; Cho, Seung Woo; Zarnegar, Brian J.; Greenleaf, William J.; Chang, Howard Y.; Khavari, Paul A. (January 2019). "Coupled Single-Cell CRISPR Screening and Epigenomic Profiling Reveals Causal Gene Regulatory Networks". Cell. 176 (1–2): 361–376.e17. doi:10.1016/j.cell.2018.11.022. PMC 6329648. PMID 30580963.[non-primary source needed]
  21. ^ Ramanathan, Muthukumar; Porter, Douglas F.; Khavari, Paul A. (March 2019). "Methods to study RNA–protein interactions". Nature Methods. 16 (3): 225–234. doi:10.1038/s41592-019-0330-1. PMC 6692137. PMID 30804549.[non-primary source needed]
  22. ^ Kretz, Markus; Siprashvili, Zurab; Chu, Ci; Webster, Dan E.; Zehnder, Ashley; Qu, Kun; Lee, Carolyn S.; Flockhart, Ross J.; Groff, Abigail F.; Chow, Jennifer; Johnston, Danielle; Kim, Grace E.; Spitale, Robert C.; Flynn, Ryan A.; Zheng, Grace X. Y.; Aiyer, Subhadra; Raj, Arjun; Rinn, John L.; Chang, Howard Y.; Khavari, Paul A. (January 2013). "Control of somatic tissue differentiation by the long non-coding RNA TINCR". Nature. 493 (7431): 231–235. Bibcode:2013Natur.493..231K. doi:10.1038/nature11661. PMC 3674581. PMID 23201690.[non-primary source needed]
  23. ^ Sen, George L.; Reuter, Jason A.; Webster, Daniel E.; Zhu, Lilly; Khavari, Paul A. (28 January 2010). "DNMT1 maintains progenitor function in self-renewing somatic tissue". Nature. 463 (7280): 563–567. Bibcode:2010Natur.463..563S. doi:10.1038/nature08683. PMC 3050546. PMID 20081831.[non-primary source needed]
  24. ^ Ji, Andrew L.; Rubin, Adam J.; Thrane, Kim; Jiang, Sizun; Reynolds, David L.; Meyers, Robin M.; Guo, Margaret G.; George, Benson M.; Mollbrink, Annelie; Bergenstråhle, Joseph; Larsson, Ludvig; Bai, Yunhao; Zhu, Bokai; Bhaduri, Aparna; Meyers, Jordan M.; Rovira-Clavé, Xavier; Hollmig, S. Tyler; Aasi, Sumaira Z.; Nolan, Garry P.; Lundeberg, Joakim; Khavari, Paul A. (September 2020). "Multimodal Analysis of Composition and Spatial Architecture in Human Squamous Cell Carcinoma". Cell. 182 (6): 1661–1662. doi:10.1016/j.cell.2020.08.043. PMC 7505493. PMID 32946785.[non-primary source needed]
  25. ^ Ungewickell, Alexander; Bhaduri, Aparna; Rios, Eon; Reuter, Jason; Lee, Carolyn S; Mah, Angela; Zehnder, Ashley; Ohgami, Robert; Kulkarni, Shashikant; Armstrong, Randall; Weng, Wen-Kai; Gratzinger, Dita; Tavallaee, Mahkam; Rook, Alain; Snyder, Michael; Kim, Youn; Khavari, Paul A (September 2015). "Genomic analysis of mycosis fungoides and Sézary syndrome identifies recurrent alterations in TNFR2". Nature Genetics. 47 (9): 1056–1060. doi:10.1038/ng.3370. PMC 6091217. PMID 26258847.[non-primary source needed]
  26. ^ Lee, Carolyn S; Bhaduri, Aparna; Mah, Angela; Johnson, Whitney L; Ungewickell, Alexander; Aros, Cody J; Nguyen, Christie B; Rios, Eon J; Siprashvili, Zurab; Straight, Aaron; Kim, Jinah; Aasi, Sumaira Z; Khavari, Paul A (October 2014). "Recurrent point mutations in the kinetochore gene KNSTRN in cutaneous squamous cell carcinoma". Nature Genetics. 46 (10): 1060–1062. doi:10.1038/ng.3091. PMC 4324615. PMID 25194279.[non-primary source needed]
  27. ^ a b "Paul Khavari, MD/PhD | 2021 SID Virtual Meeting | 2021 SID Awardees". SID Annual Meeting. Retrieved 2021-05-10.
  28. ^ "Lila and Murray Gruber Memorial Cancer Research Award and Lectureship". www.aad.org. Retrieved 2021-10-18.
  29. ^ "Three faculty members elected to Institute of Medicine". News Center (in Samoan). Retrieved 2021-10-18.
  30. ^ "American Skin Association (ASA) Celebrates 25th Anniversary". American Skin Association (Press release). Retrieved 2021-10-18.
  31. ^ "Tanioku Kihei Memorial Award - The Japanese Society for Investigative Dermatology". www.jsid.org. Retrieved 2021-10-18.
  32. ^ П.М. Мазуркин (2013). ДИНАМИКА АЛЬФА-АКТИВНОСТИ ОБРАЗЦА 239PU В РАЗЛИЧНЫХ ШКАЛАХ ВРЕМЕНИ. Science and World. 2 (2). doi:10.18411/a-2017-023.
  33. ^ "Med School appointments, promotions: 6/3/98". Stanford. Retrieved 2021-10-18.
  34. ^ "Two young Stanford scientists receive Presidential award (1/97)". Stanford. Retrieved 2021-10-18.
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