Patrick McDonough may refer to:
- Pat McDonough (born 1943), Republican member of the Maryland House of Delegates
- Patrick McDonough (cyclist) (born 1961), retired track cyclist from the United States
- Patrick F. McDonough (died 2001), American police officer, attorney, and member of the Boston City Council
- Patrick J. McDonough (1911–1980), American politician in Massachusetts
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