Thymus-specific serine protease is an enzyme that in humans is encoded by the PRSS16 gene.[5][6]
| PRSS16 | |||||||||||||||||||||||||||||||||||||||||||||||||||
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| Aliases | PRSS16, TSSP, protease, serine 16, serine protease 16 | ||||||||||||||||||||||||||||||||||||||||||||||||||
| External IDs | OMIM: 607169; MGI: 1859181; HomoloGene: 38106; GeneCards: PRSS16; OMA:PRSS16 - orthologs | ||||||||||||||||||||||||||||||||||||||||||||||||||
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This gene encodes a serine protease expressed exclusively in the thymus. It is thought to play a role in the alternative antigen presenting pathway used by cortical thymic epithelial cells during the positive selection of T cells.
The gene is found in the large histone gene cluster on chromosome 6, near the major histocompatibility complex (MHC) class I region. A second transcript variant has been described, but its full length nature has not been determined.[6]
References
edit- ^ a b c GRCh38: Ensembl release 89: ENSG00000112812 – Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000006179 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ Bowlus CL, Ahn J, Chu T, Gruen JR (Nov 1999). "Cloning of a novel MHC-encoded serine peptidase highly expressed by cortical epithelial cells of the thymus". Cellular Immunology. 196 (2): 80–6. doi:10.1006/cimm.1999.1543. PMID 10527559.
- ^ a b "Entrez Gene: PRSS16 protease, serine, 16 (thymus)".
Further reading
edit- Lie BA, Viken MK, Akselsen HE, et al. (2007). "Association analysis in type 1 diabetes of the PRSS16 gene encoding a thymus-specific serine protease". Hum. Immunol. 68 (7): 592–8. doi:10.1016/j.humimm.2007.03.009. PMID 17584581.
- Luther C, Wienhold W, Oehlmann R, et al. (2005). "Alternatively spliced transcripts of the thymus-specific protease PRSS16 are differentially expressed in human thymus". Genes Immun. 6 (1): 1–7. doi:10.1038/sj.gene.6364142. PMID 15592422.
- Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
- Mungall AJ, Palmer SA, Sims SK, et al. (2003). "The DNA sequence and analysis of human chromosome 6". Nature. 425 (6960): 805–11. doi:10.1038/nature02055. PMID 14574404.
- Lie BA, Akselsen HE, Bowlus CL, et al. (2003). "Polymorphisms in the gene encoding thymus-specific serine protease in the extended HLA complex: a potential candidate gene for autoimmune and HLA-associated diseases". Genes Immun. 3 (5): 306–12. doi:10.1038/sj.gene.6363858. PMID 12140752.
- Gruen JR, Nalabolu SR, Chu TW, et al. (1997). "A transcription map of the major histocompatibility complex (MHC) class I region". Genomics. 36 (1): 70–85. doi:10.1006/geno.1996.0427. PMID 8812418.
External links
edit- PRSS16 human gene location in the UCSC Genome Browser.
- PRSS16 human gene details in the UCSC Genome Browser.
 | This article on a gene on human chromosome 6 is a stub. You can help Wikipedia by expanding it. |