Peptidyl-prolyl cis-trans isomerase H is an enzyme that in humans is encoded by the PPIH gene .[ 5] [ 6] [ 7]
The protein encoded by this gene is a member of the peptidyl-prolyl cis-trans isomerase (PPIase) family. PPIases catalyze the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and accelerate the folding of proteins. This protein is a specific component of the complex that includes pre-mRNA processing factors PRPF3, PRPF4, and PRPF18, as well as U4/U5/U6 tri-snRNP. This protein has been shown to possess PPIase activity and may act as a protein chaperone that mediates the interactions between different proteins inside the spliceosome.[ 7]
^ a b c GRCh38: Ensembl release 89: ENSG00000171960 – Ensembl , May 2017^ a b c GRCm38: Ensembl release 89: ENSMUSG00000060288 – Ensembl , May 2017^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ Horowitz DS, Kobayashi R, Krainer AR (Dec 1997). "A new cyclophilin and the human homologues of yeast Prp3 and Prp4 form a complex associated with U4/U6 snRNPs" . RNA . 3 (12): 1374–87. PMC 1369579 PMID 9404889 . ^ Teigelkamp S, Achsel T, Mundt C, Gothel SF, Cronshagen U, Lane WS, Marahiel M, Luhrmann R (May 1998). "The 20kD protein of human U4/U6.U5 tri-snRNPs is a novel cyclophilin that forms a complex with the U4/U6-specific 60kD and 90kD proteins" . RNA . 4 (2): 127–41. PMC 1369602 PMID 9570313 . ^ a b "Entrez Gene: PPIH peptidylprolyl isomerase H (cyclophilin H)" .
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