PPARGC1B

Peroxisome proliferator-activated receptor gamma coactivator 1-beta is a protein that in humans is encoded by the PPARGC1B gene.

PPARGC1B
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3SP6
Identifiers
Aliases	PPARGC1B, ERRL1, PERC, PGC-1(beta), PGC1B, PPARG coactivator 1 beta
External IDs	OMIM: 608886; MGI: 2444934; HomoloGene: 15776; GeneCards: PPARGC1B; OMA:PPARGC1B - orthologs
Gene location (Human) Chr. Chromosome 5 (human) Band 5q32 Start 149,730,298 bp End 149,855,022 bp
Gene location (Mouse) Chr. Chromosome 18 (mouse) Band 18|18 E1 Start 61,431,207 bp End 61,533,502 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in endothelial cell secondary oocyte germinal epithelium jejunal mucosa duodenum testicle Brodmann area 23 gonad apex of heart monocyte Top expressed in right ventricle brown adipose tissue ciliary body cerebellar vermis epithelium of stomach lobe of cerebellum left colon crypt of lieberkuhn of small intestine olfactory tubercle pyloric antrum More reference expression data BioGPS n/a
Gene ontology Molecular function transcription coregulator activity AF-2 domain binding nuclear receptor coactivator activity RNA binding nucleic acid binding transcription factor binding estrogen receptor binding Cellular component mediator complex mitochondrion nucleus nucleoplasm Biological process mitochondrial transcription regulation of transcription, DNA-templated ossification actin filament organization positive regulation of osteoclast differentiation positive regulation of DNA-binding transcription factor activity response to glucocorticoid bone trabecula formation positive regulation of bone resorption transcription, DNA-templated positive regulation of transcription, DNA-templated cellular response to reactive oxygen species positive regulation of alkaline phosphatase activity response to cAMP positive regulation of phosphorylation negative regulation of transcription, DNA-templated intracellular estrogen receptor signaling pathway positive regulation of transcription by RNA polymerase II positive regulation of cold-induced thermogenesis regulation of nucleic acid-templated transcription Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 133522 170826 Ensembl ENSG00000155846 ENSMUSG00000033871 UniProt Q86YN6 Q8VHJ7 RefSeq (mRNA) NM_001172698 NM_001172699 NM_133263 NM_133249 NM_001364996 RefSeq (protein) NP_001166169 NP_001166170 NP_573570 NP_573512 NP_001351925 Location (UCSC) Chr 5: 149.73 – 149.86 Mb Chr 18: 61.43 – 61.53 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

See also

• PPARGC1A
• Peroxisome proliferator-activated receptor
• Peroxisome proliferator-activated receptor alpha
• Peroxisome proliferator-activated receptor delta
• Peroxisome proliferator-activated receptor gamma
• Transcription coregulator

Further reading

• Handschin C, Spiegelman BM (2007). "Peroxisome proliferator-activated receptor gamma coactivator 1 coactivators, energy homeostasis, and metabolism". Endocr. Rev. 27 (7): 728–35. doi:10.1210/er.2006-0037. PMID 17018837.
• Esterbauer H, Oberkofler H, Krempler F, Patsch W (2000). "Human peroxisome proliferator activated receptor gamma coactivator 1 (PPARGC1) gene: cDNA sequence, genomic organization, chromosomal localization, and tissue expression". Genomics. 62 (1): 98–102. doi:10.1006/geno.1999.5977. PMID 10585775.
• Knutti D, Kaul A, Kralli A (2000). "A tissue-specific coactivator of steroid receptors, identified in a functional genetic screen". Mol. Cell. Biol. 20 (7): 2411–22. doi:10.1128/MCB.20.7.2411-2422.2000. PMC 85422. PMID 10713165.
• Lin J, Puigserver P, Donovan J, et al. (2002). "Peroxisome proliferator-activated receptor gamma coactivator 1beta (PGC-1beta ), a novel PGC-1-related transcription coactivator associated with host cell factor". J. Biol. Chem. 277 (3): 1645–8. doi:10.1074/jbc.C100631200. PMID 11733490.
• Lacquemant C, Chikri M, Boutin P, et al. (2002). "No association between the G482S polymorphism of the proliferator-activated receptor-gamma coactivator-1 (PGC-1) gene and Type II diabetes in French Caucasians". Diabetologia. 45 (4): 602–3, author reply 604. doi:10.1007/s00125-002-0783-z. PMID 12032643.
• Hara K, Tobe K, Okada T, et al. (2003). "A genetic variation in the PGC-1 gene could confer insulin resistance and susceptibility to Type II diabetes". Diabetologia. 45 (5): 740–3. doi:10.1007/s00125-002-0803-z. PMID 12107756.
• Huss JM, Kopp RP, Kelly DP (2002). "Peroxisome proliferator-activated receptor coactivator-1alpha (PGC-1alpha) coactivates the cardiac-enriched nuclear receptors estrogen-related receptor-alpha and -gamma. Identification of novel leucine-rich interaction motif within PGC-1alpha". J. Biol. Chem. 277 (43): 40265–74. doi:10.1074/jbc.M206324200. PMID 12181319.
• Hentschke M, Süsens U, Borgmeyer U (2003). "PGC-1 and PERC, coactivators of the estrogen receptor-related receptor gamma". Biochem. Biophys. Res. Commun. 299 (5): 872–9. doi:10.1016/S0006-291X(02)02753-5. PMID 12470660.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Shiraki T, Sakai N, Kanaya E, Jingami H (2003). "Activation of orphan nuclear constitutive androstane receptor requires subnuclear targeting by peroxisome proliferator-activated receptor gamma coactivator-1 alpha. A possible link between xenobiotic response and nutritional state". J. Biol. Chem. 278 (13): 11344–50. doi:10.1074/jbc.M212859200. PMID 12551939.
• Hammarstedt A, Jansson PA, Wesslau C, et al. (2003). "Reduced expression of PGC-1 and insulin-signaling molecules in adipose tissue is associated with insulin resistance". Biochem. Biophys. Res. Commun. 301 (2): 578–82. doi:10.1016/S0006-291X(03)00014-7. PMID 12565902.
• Meirhaeghe A, Crowley V, Lenaghan C, et al. (2003). "Characterization of the human, mouse and rat PGC1 beta (peroxisome-proliferator-activated receptor-gamma co-activator 1 beta) gene in vitro and in vivo". Biochem. J. 373 (Pt 1): 155–65. doi:10.1042/BJ20030200. PMC 1223480. PMID 12678921.
• Patti ME, Butte AJ, Crunkhorn S, et al. (2003). "Coordinated reduction of genes of oxidative metabolism in humans with insulin resistance and diabetes: Potential role of PGC1 and NRF1". Proc. Natl. Acad. Sci. U.S.A. 100 (14): 8466–71. Bibcode:2003PNAS..100.8466P. doi:10.1073/pnas.1032913100. PMC 166252. PMID 12832613.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Ling C, Poulsen P, Carlsson E, et al. (2004). "Multiple environmental and genetic factors influence skeletal muscle PGC-1alpha and PGC-1beta gene expression in twins". J. Clin. Invest. 114 (10): 1518–26. doi:10.1172/JCI21889. PMC 525741. PMID 15546003.
• Andersen G, Wegner L, Yanagisawa K, et al. (2006). "Evidence of an association between genetic variation of the coactivator PGC-1beta and obesity". J. Med. Genet. 42 (5): 402–7. doi:10.1136/jmg.2004.026278. PMC 1736055. PMID 15863669.
• Staiger H, Staiger K, Haas C, et al. (2005). "Fatty acid-induced differential regulation of the genes encoding peroxisome proliferator-activated receptor-gamma coactivator-1alpha and -1beta in human skeletal muscle cells that have been differentiated in vitro". Diabetologia. 48 (10): 2115–8. doi:10.1007/s00125-005-1895-z. PMID 16132959.
• Wirtenberger M, Tchatchou S, Hemminki K, et al. (2006). "Associations of genetic variants in the estrogen receptor coactivators PPARGC1A, PPARGC1B and EP300 with familial breast cancer". Carcinogenesis. 27 (11): 2201–8. doi:10.1093/carcin/bgl067. PMID 16704985.

External links

• PPARGC1B protein, human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
• NURSA C21

This article incorporates text from the United States National Library of Medicine, which is in the public domain.