PLCD1

1-Phosphatidylinositol-4,5-bisphosphate phosphodiesterase delta-1 is an enzyme that in humans is encoded by the PLCD1 gene. PLCd1 is essential to maintain homeostasis of the skin.

PLCD1
Identifiers
Aliases	PLCD1, NDNC3, PLC-III, phospholipase C delta 1
External IDs	OMIM: 602142; MGI: 97614; HomoloGene: 21252; GeneCards: PLCD1; OMA:PLCD1 - orthologs
Gene location (Human) Chr. Chromosome 3 (human) Band 3p22.2 Start 38,007,496 bp End 38,029,642 bp
Gene location (Mouse) Chr. Chromosome 9 (mouse) Band 9|9 F3 Start 118,900,595 bp End 118,922,570 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in olfactory bulb mucosa of transverse colon thoracic diaphragm right testis left testis dorsal motor nucleus of vagus nerve Descending thoracic aorta inferior olivary nucleus ascending aorta gingival epithelium Top expressed in esophagus calvaria lip transitional epithelium of urinary bladder membranous bone body of femur ascending aorta corneal stroma Dermatocranium ankle More reference expression data BioGPS More reference expression data
Gene ontology Molecular function GTPase activating protein binding calcium ion binding phosphatidylinositol phosphate binding phosphatidylserine binding signal transducer activity metal ion binding phosphatidic acid binding phosphoric diester hydrolase activity phospholipase C activity hydrolase activity phosphatidylinositol phospholipase C activity phosphatidylinositol-4,5-bisphosphate binding protein binding Cellular component cytoplasm cytosol plasma membrane extracellular exosome Biological process intracellular signal transduction lipid metabolism labyrinthine layer blood vessel development inositol phosphate metabolic process lipid catabolic process regulation of cell population proliferation angiogenesis phospholipid metabolic process signal transduction inositol trisphosphate biosynthetic process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 5333 18799 Ensembl ENSG00000187091 ENSMUSG00000010660 UniProt P51178 Q8R3B1 RefSeq (mRNA) NM_001130964 NM_006225 NM_001293648 NM_019676 RefSeq (protein) NP_001124436 NP_006216 NP_001280577 NP_062650 Location (UCSC) Chr 3: 38.01 – 38.03 Mb Chr 9: 118.9 – 118.92 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

See also

Phospholipase C

Further reading

• Yagisawa H (2006). "Nucleocytoplasmic shuttling of phospholipase C-delta1: a link to Ca2+". J. Cell. Biochem. 97 (2): 233–43. doi:10.1002/jcb.20677. PMID 16240320. S2CID 84240929.
• Cefai D, Debre P, Kaczorek M, et al. (1991). "Human immunodeficiency virus-1 glycoproteins gp120 and gp160 specifically inhibit the CD3/T cell-antigen receptor phosphoinositide transduction pathway". J. Clin. Invest. 86 (6): 2117–24. doi:10.1172/JCI114950. PMC 329852. PMID 1979339.
• Zauli G, Previati M, Caramelli E, et al. (1995). "Exogenous human immunodeficiency virus type-1 Tat protein selectively stimulates a phosphatidylinositol-specific phospholipase C nuclear pathway in the Jurkat T cell line". Eur. J. Immunol. 25 (9): 2695–700. doi:10.1002/eji.1830250944. PMID 7589147. S2CID 20562627.
• Cheng HF, Jiang MJ, Chen CL, et al. (1995). "Cloning and identification of amino acid residues of human phospholipase C delta 1 essential for catalysis". J. Biol. Chem. 270 (10): 5495–505. doi:10.1074/jbc.270.10.5495. PMID 7890667.
• Ghosh S, Pawelczyk T, Lowenstein JM (1997). "Phospholipase C isoforms delta 1 and delta 3 from human fibroblasts. High-yield expression in Escherichia coli, simple purification, and properties". Protein Expr. Purif. 9 (2): 262–78. doi:10.1006/prep.1996.0682. PMID 9056492.
• Chen P, Mayne M, Power C, Nath A (1997). "The Tat protein of HIV-1 induces tumor necrosis factor-alpha production. Implications for HIV-1-associated neurological diseases". J. Biol. Chem. 272 (36): 22385–8. doi:10.1074/jbc.272.36.22385. PMID 9278385.
• Park ES, Won JH, Han KJ, et al. (1998). "Phospholipase C-delta1 and oxytocin receptor signalling: evidence of its role as an effector". Biochem. J. 331 (1): 283–9. doi:10.1042/bj3310283. PMC 1219350. PMID 9512491.
• Shimohama S, Kamiya S, Fujii M, et al. (1998). "Mutation in the pleckstrin homology domain of the human phospholipase C-delta 1 gene is associated with loss of function". Biochem. Biophys. Res. Commun. 245 (3): 722–8. doi:10.1006/bbrc.1998.8307. PMID 9588182.
• Mayne M, Bratanich AC, Chen P, et al. (1998). "HIV-1 tat molecular diversity and induction of TNF-alpha: implications for HIV-induced neurological disease". Neuroimmunomodulation. 5 (3–4): 184–92. doi:10.1159/000026336. PMID 9730685. S2CID 19529677.
• Haughey NJ, Holden CP, Nath A, Geiger JD (1999). "Involvement of inositol 1,4,5-trisphosphate-regulated stores of intracellular calcium in calcium dysregulation and neuron cell death caused by HIV-1 protein tat". J. Neurochem. 73 (4): 1363–74. doi:10.1046/j.1471-4159.1999.0731363.x. PMID 10501179. S2CID 25410140.
• Mayne M, Holden CP, Nath A, Geiger JD (2000). "Release of calcium from inositol 1,4,5-trisphosphate receptor-regulated stores by HIV-1 Tat regulates TNF-alpha production in human macrophages". J. Immunol. 164 (12): 6538–42. doi:10.4049/jimmunol.164.12.6538. PMID 10843712.
• Nash MS, Young KW, Willars GB, et al. (2001). "Single-cell imaging of graded Ins(1,4,5)P3 production following G-protein-coupled-receptor activation". Biochem. J. 356 (Pt 1): 137–42. doi:10.1042/0264-6021:3560137. PMC 1221821. PMID 11336645.
• Ananthanarayanan B, Das S, Rhee SG, et al. (2002). "Membrane targeting of C2 domains of phospholipase C-delta isoforms". J. Biol. Chem. 277 (5): 3568–75. doi:10.1074/jbc.M109705200. PMID 11706040.
• Keshamouni VG, Mattingly RR, Reddy KB (2002). "Mechanism of 17-beta-estradiol-induced Erk1/2 activation in breast cancer cells. A role for HER2 AND PKC-delta". J. Biol. Chem. 277 (25): 22558–65. doi:10.1074/jbc.M202351200. PMID 11960991.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Bennasser Y, Badou A, Tkaczuk J, Bahraoui E (2003). "Signaling pathways triggered by HIV-1 Tat in human monocytes to induce TNF-alpha". Virology. 303 (1): 174–80. doi:10.1006/viro.2002.1676. PMID 12482669.
• Guo Y, Philip F, Scarlata S (2003). "The Pleckstrin homology domains of phospholipases C-beta and -delta confer activation through a common site". J. Biol. Chem. 278 (32): 29995–30004. doi:10.1074/jbc.M301438200. PMID 12761218.
• Caprini M, Gomis A, Cabedo H, et al. (2003). "GAP43 stimulates inositol trisphosphate-mediated calcium release in response to hypotonicity". EMBO J. 22 (12): 3004–14. doi:10.1093/emboj/cdg294. PMC 162146. PMID 12805215.
• Kim JY, Kim H, Lee SG, et al. (2003). "Amyloid beta peptide (Abeta42) activates PLC-delta1 promoter through the NF-kappaB binding site". Biochem. Biophys. Res. Commun. 310 (3): 904–9. doi:10.1016/j.bbrc.2003.09.100. PMID 14550290.

External links

• WikiGenes entry for PLCD1