PD-168,077 is a drug which acts as a dopamine agonist selective for the D4 subtype,[1][2] which is used for researching the role of D4 receptors in the brain,[3][4][5] particularly relating to learning and memory.[6] The propensity to induce penile erections in rats means it could be used for this also?[7]

PD-168,077 Structure.svg
  • N-([4-(2-cyanophenyl)piperazin-1-yl]methyl)-3-methylbenzamide
PubChem CID
CompTox Dashboard (EPA)
Chemical and physical data
Molar mass334.423 g·mol−1
3D model (JSmol)
  • Cc2cc(ccc2)C(=O)NCN(CC3)CCN3c1ccccc1C#N
  • InChI=1S/C20H22N4O/c1-16-5-4-7-17(13-16)20(25)22-15-23-9-11-24(12-10-23)19-8-3-2-6-18(19)14-21/h2-8,13H,9-12,15H2,1H3,(H,22,25) ☒N
 ☒NcheckY (what is this?)  (verify)


  1. ^ Clifford JJ, Waddington JL (May 2000). "Topographically based search for an "Ethogram" among a series of novel D(4) dopamine receptor agonists and antagonists". Neuropsychopharmacology. 22 (5): 538–44. doi:10.1016/S0893-133X(99)00141-4. PMID 10731629.
  2. ^ Matulenko MA, Hakeem AA, Kolasa T, Nakane M, Terranova MA, Uchic ME, Miller LN, Chang R, Donnelly-Roberts DL, Namovic MT, Moreland RB, Brioni JD, Stewart AO (July 2004). "Synthesis and functional activity of (2-aryl-1-piperazinyl)-N-(3-methylphenyl)acetamides: selective dopamine D4 receptor agonists". Bioorganic & Medicinal Chemistry. 12 (13): 3471–83. doi:10.1016/j.bmc.2004.04.035. PMID 15186832.
  3. ^ Wang X, Zhong P, Gu Z, Yan Z (October 2003). "Regulation of NMDA receptors by dopamine D4 signaling in prefrontal cortex". Journal of Neuroscience. 23 (30): 9852–61. doi:10.1523/JNEUROSCI.23-30-09852.2003. PMC 6740894. PMID 14586014.
  4. ^ Melis MR, Succu S, Sanna F, Melis T, Mascia MS, Enguehard-Gueiffier C, Hubner H, Gmeiner P, Gueiffier A, Argiolas A (October 2006). "PIP3EA and PD-168077, two selective dopamine D4 receptor agonists, induce penile erection in male rats: site and mechanism of action in the brain". The European Journal of Neuroscience. 24 (7): 2021–30. doi:10.1111/j.1460-9568.2006.05043.x. PMID 17067298. S2CID 36871301.
  5. ^ Succu S, Sanna F, Melis T, Boi A, Argiolas A, Melis MR (March 2007). "Stimulation of dopamine receptors in the paraventricular nucleus of the hypothalamus of male rats induces penile erection and increases extra-cellular dopamine in the nucleus accumbens: Involvement of central oxytocin". Neuropharmacology. 52 (3): 1034–43. doi:10.1016/j.neuropharm.2006.10.019. PMID 17164075. S2CID 36595888.
  6. ^ Bernaerts P, Tirelli E (June 2003). "Facilitatory effect of the dopamine D4 receptor agonist PD168,077 on memory consolidation of an inhibitory avoidance learned response in C57BL/6J mice". Behavioural Brain Research. 142 (1–2): 41–52. doi:10.1016/S0166-4328(02)00371-6. PMID 12798264. S2CID 21960608.
  7. ^ Melis, Maria Rosaria; Succu, Salvatora; Sanna, Fabrizio; Melis, Tiziana; Mascia, Maria Stefania; Enguehard-Gueiffier, Cécile; Hubner, Harald; Gmeiner, Peter; Gueiffier, Alain; Argiolas, Antonio (2006). "PIP3EA and PD-168077, two selective dopamine D4 receptor agonists, induce penile erection in male rats: site and mechanism of action in the brain". European Journal of Neuroscience. 24 (7): 2021–2030. doi:10.1111/j.1460-9568.2006.05043.x. ISSN 0953-816X.