Protein-L-isoaspartate(D-aspartate) O-methyltransferase is an enzyme that in humans is encoded by the PCMT1 gene.[5][6][7]

PCMT1
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesPCMT1, PIMT, protein-L-isoaspartate (D-aspartate) O-methyltransferase
External IDsOMIM: 176851; MGI: 97502; HomoloGene: 55895; GeneCards: PCMT1; OMA:PCMT1 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)
RefSeq (protein)

n/a

Location (UCSC)Chr 6: 149.75 – 149.81 MbChr 10: 7.63 – 7.68 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Three classes of protein carboxyl methyltransferases, distinguished by their methyl-acceptor substrate specificity, have been found in prokaryotic and eukaryotic cells. The type II enzyme catalyzes the transfer of a methyl group from S-adenosyl-L-methionine to the free carboxyl groups of D-aspartyl and L-isoaspartyl residues. These methyl-accepting residues result from the spontaneous deamidation, isomerization, and racemization of normal L-aspartyl and L-asparaginyl residues and represent sites of covalent damage to aging proteins PCMT1 (EC 2.1.1.77) is a protein repair enzyme that initiates the conversion of abnormal D-aspartyl and L-isoaspartyl residues to the normal L-aspartyl form.[supplied by OMIM][7]

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000120265Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000019795Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ MacLaren DC, O'Connor CM, Xia YR, Mehrabian M, Klisak I, Sparkes RS, Clarke S, Lusis AJ (Feb 1993). "The L-isoaspartyl/D-aspartyl protein methyltransferase gene (PCMT1) maps to human chromosome 6q22.3-6q24 and the syntenic region of mouse chromosome 10". Genomics. 14 (4): 852–6. doi:10.1016/S0888-7543(05)80104-1. PMID 1478665.
  6. ^ DeVry CG, Clarke S (Jun 1999). "Assignment of the protein L-isoaspartate (D-aspartate) O-methyltransferase gene (PCMT1) to human chromosome bands 6q24→q25 with radiation hybrid mapping". Cytogenet Cell Genet. 84 (1–2): 130–1. doi:10.1159/000015239. PMID 10343128. S2CID 38976877.
  7. ^ a b "Entrez Gene: PCMT1 protein-L-isoaspartate (D-aspartate) O-methyltransferase".

Further reading

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