PABPC3

Polyadenylate-binding protein 3 is a protein that in humans is encoded by the PABPC3 gene. PABPC3 is a member of a larger family of poly(A)-binding proteins in the human genome.

PABPC3
Available structures PDB Human UniProt search: PDBe RCSB List of PDB id codes 4IVE
Identifiers
Aliases	PABPC3, PABP3, PABPL3, tPABP, poly(A) binding protein cytoplasmic 3
External IDs	OMIM: 604680; HomoloGene: 118007; GeneCards: PABPC3; OMA:PABPC3 - orthologs
Gene location (Human) Chr. Chromosome 13 (human) Band 13q12.13 Start 25,096,136 bp End 25,099,254 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in parotid gland epithelium of nasopharynx amniotic fluid pancreatic ductal cell seminal vesicula pylorus lactiferous duct buccal mucosa cell oral cavity vulva n/a More reference expression data BioGPS More reference expression data
Gene ontology Molecular function poly(A) binding RNA binding nucleic acid binding mRNA 3'-UTR binding poly(U) RNA binding Cellular component cytoplasm extracellular exosome cytosol nucleus cytoplasmic stress granule ribonucleoprotein complex Biological process mRNA metabolic process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 5042 n/a Ensembl ENSG00000151846 n/a UniProt Q9H361 n/a RefSeq (mRNA) NM_030979 n/a RefSeq (protein) NP_112241 n/a Location (UCSC) Chr 13: 25.1 – 25.1 Mb n/a PubMed search n/a
Wikidata
View/Edit Human

Further reading

• Marques AC, Dupanloup I, Vinckenbosch N, et al. (2006). "Emergence of young human genes after a burst of retroposition in primates". PLOS Biol. 3 (11): e357. doi:10.1371/journal.pbio.0030357. PMC 1251493. PMID 16201836.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Féral C, Guellaën G, Pawlak A (2002). "Human testis expresses a specific poly(A)-binding protein". Nucleic Acids Res. 29 (9): 1872–83. doi:10.1093/nar/29.9.1872. PMC 37253. PMID 11328870.
• Wiemann S, Weil B, Wellenreuther R, et al. (2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs". Genome Res. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166.
• Hoshino S, Imai M, Kobayashi T, et al. (1999). "The eukaryotic polypeptide chain releasing factor (eRF3/GSPT) carrying the translation termination signal to the 3'-Poly(A) tail of mRNA. Direct association of erf3/GSPT with polyadenylate-binding protein". J. Biol. Chem. 274 (24): 16677–80. doi:10.1074/jbc.274.24.16677. PMID 10358005.

External links

• PDBe-KB provides an overview of all the structure information available in the PDB for Human Polyadenylate-binding protein 3 (PABPC3)