p53 is a tumor suppressor protein.
P53 may also refer to:
- p53 (band), an experimental music group
- p53 (album), their 1996 live album
- Curtiss XP-53, an American experimental fighter aircraft
- HMS Ultor (P53), a submarine of the Royal Navy
- INS Savitri (P53), a patrol vessel of the Indian Navy
- P53 road (Ukraine)
- Papyrus 53, a biblical manuscript
- Pattern 1853 Enfield, a British rifle-musket
- P53, a state regional road in Latvia
- P53, a ThinkPad P series laptop
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