Osawatomie may refer to:
- Osawatomie, Kansas
- Osawatomie High School
- Battle of Osawatomie, engagement in Bleeding Kansas struggle
- Osawatomie Brown, an 1859 play by Kate Edwards about John Brown.
- John "Osawatomie" Brown, the abolitionist.
- Osawatomie (periodical)
This disambiguation page lists articles associated with the title Osawatomie.
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