Orthoretrovirinae is a subfamily of viruses belonging to Retroviridae, a family of enveloped viruses that replicate in a host cell through the process of reverse transcription. The subfamily currently includes six genera, of which Lentivirus contains the human immunodeficiency virus (HIV). These viruses cause a variety of tumors, malignancies and immune deficiency disease in man, other mammals and birds. A few, like SIV, apparently cause no disease in their natural hosts.

Virus classification e
(unranked): Virus
Phylum: incertae sedis
Class: incertae sedis
Order: Ortervirales
Family: Retroviridae
Subfamily: Orthoretrovirinae